Mitochondrial targeting of α-tocopheryl succinate enhances its pro-apoptotic efficacy: A new paradigm for effective cancer therapy
Publication Type: Journal Articles (Refereed Article)
Year of Publication: 2011
Author(s): Dong, Lan-feng, Jameson, Victoria J.A., Tilly, David Patrice, Prochazka, Lubomir, Rohlena, Jakub, Valis, Karel, Truksa, Jaroslav, Zobalova, Renata, Mahdavian, Elahe, Kluckova, Katarina, Stantic, Marina, Stursa, Jan, Freeman, Ruth, Witting, Paul K., Norberg, Erik, Goodwin, Jacob, Salvatore, Brian A., Novotna, Jana, Turanek, Jaroslav, Ledvina, Miroslav, Hozak, Pavel, Zhivotovsky, Boris, Coster, Mark J., Ralph, Stephen John, Smith, Robin A.J., Neuzil, Jiri

α-Tocopheryl succinate causes mitochondrial permeabilization by preferential formation of Bak channels
Publication Type: Journal Articles (Refereed Article)
Year of Publication: 2010
Author(s): Prochazka, Lubomir, Dong, Lan-feng, Valis, Karel, Freeman, Ruth, Ralph, Stephen John, Turanek, Jaroslav, Neuzil, Jiri

Suppression of Tumor Growth In vivo by the Mitocan α-tocopheryl Succinate Requires Respiratory Complex II
Publication Type: Journal Articles (Refereed Article)
Year of Publication: 2009
Author(s): Dong, Lan-feng, Freeman, Ruth, Liu, Ji, Zobalova, Renata, Marin-Hernandez, Alvaro, Stantic, Marina, Rohlena, Jakub, Valis, Karel, Rodriguez-Enriquez, Sara, Butcher, Bevan, Goodwin, Jacob, Brunk, Ulf T., Witting, Paul K., Moreno-Sanchez, Rafael, Scheffler, Immo E., Ralph, Stephen John, Neuzil, Jiri

α-Tocopheryl succinate induces apoptosis by targeting ubiquinone-binding sites in mitochondrial respiratory complex II
Publication Type: Journal Articles (Refereed Article)
Year of Publication: 2008
Author(s): Dong, Lan-feng, Low, Pauline, Dyason, Jeffrey Clifford, Wang, Xiufang, Prochazka, L, Witting, PK, Freeman, Ruth, Swettenham, E, Valis, K, Liu, James, Zobalova, Renata, Turanek, J, Spitz, DR, Domann, FE, Scheffler, IE, Ralph, Stephen John, Neuzil, Jiri

Vitamin E analogues as a novel group of mitocans: anti-cancer agents that act by targeting mitochondria
Publication Type: Journal Articles (Refereed Article)
Year of Publication: 2007
Author(s): Neuzil, Jiri, Dong, Lan-feng, Ramanathapuram, Lalitha, Hahn, Tobias, Chladova, Miroslava, Wang, Xiufang, Zobalova, Renata, Prochazka, Lubomir, Gold, Mikhal, Freeman, Ruth, Turanek, Jaroslav, Akporiaye, Emmanuel T., Dyason, Jeffrey Clifford, Ralph, Stephen John

Mitocans as anti-cancer agents targeting mitochondria: lessons from studies with vitamin E analogues, inhibitors of complex II
Publication Type: Journal Articles (Refereed Article)
Year of Publication: 2007
Author(s): Neuzil, Jiri, Dyason, Jeffrey Clifford, Freeman, Ruth, Dong, Lan-feng, Prochazka, Lubomir, Wang, Xiufang, Scheffler, Immo, Ralph, Stephen John

Role of thioredoxin-1 in apoptosis induction by α-tocopheryl succinate and TNF-related apoptosis-inducing ligand in mesothelioma cells
Publication Type: Journal Articles (Refereed Article)
Year of Publication: 2006
Author(s): Freeman, Ruth, Neuzil, Jiri