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dc.contributor.authorBerners-Price, Sue
dc.contributor.authorG. Appleton, Trevor
dc.date.accessioned2017-09-22T01:41:07Z
dc.date.available2017-09-22T01:41:07Z
dc.date.issued2000
dc.date.modified2007-03-10T07:31:25Z
dc.identifier.isbn0896035999
dc.identifier.urihttp://hdl.handle.net/10072/1033
dc.description.abstractThe antitumor properties of platinum-containing drugs are attributable in large measure to the kinetics of their ligand displacement reactions. As is discussed at length in other contributions to this volume, their primary target is believed to be nitrogen donor atoms in the nucleobases of DNA. The bonds formed between the metal ion and these atoms must be sufficiently long-lived to interfere with the process of cell division, or to trigger the intracellular mechanisms that recognize irreparable damage to a cell. Bonds between the nucleobase nitrogen atoms and platinum(II) clearly fulfil this requirement. Metal ions that form labile bonds with the nucleobase nitrogen atoms cannot act in a similar way and do not give active compounds (1).
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherHumana Press
dc.publisher.placeTotowa,NewJersey USA
dc.publisher.urihttps://link.springer.com/chapter/10.1007/978-1-59259-012-4_1
dc.relation.ispartofbooktitlePlatinum-Based Drugs in Cancer Therapy
dc.relation.ispartofpagefrom3
dc.relation.ispartofpageto35
dc.subject.fieldofresearchHistory and Archaeology
dc.subject.fieldofresearchcode21
dc.titleThe Chemistry of Cisplatin in Aqueous Solution
dc.typeBook chapter
dc.type.descriptionB1 - Chapters
dc.type.codeB - Book Chapters
gro.facultyOffice of the Snr Dep Vice Chancellor, Institute for Glycomics
gro.date.issued2000
gro.hasfulltextNo Full Text
gro.griffith.authorBerners-Price, Sue J.


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