dc.contributor.author | Liakatos, A | |
dc.contributor.author | Kiefel, MJ | |
dc.contributor.author | Fleming, F | |
dc.contributor.author | Coulson, B | |
dc.contributor.author | von Itzstein, M | |
dc.date.accessioned | 2018-01-23T01:00:21Z | |
dc.date.available | 2018-01-23T01:00:21Z | |
dc.date.issued | 2006 | |
dc.date.modified | 2009-10-19T05:23:02Z | |
dc.identifier.issn | 0968-0896 | |
dc.identifier.doi | 10.1016/j.bmc.2005.08.057 | |
dc.identifier.uri | http://hdl.handle.net/10072/13716 | |
dc.description.abstract | Rotaviruses are the most significant cause of gastroenteritis in young children and are responsible for over 600,000 infant deaths annually. The rotaviral haemagglutinin protein (VP8*) of some strains has been implicated in early recognition and binding events of host cell-surface sialoglycoconjugates, and is therefore an attractive target for potential therapeutic intervention. Since N-acetylneuraminic acid a(2,3)-linked to galactose is believed to be the minimum binding epitope of rotavirus to host cells, we report here our development of an efficient and flexible synthetic route to a range of lactose-based sialylmimetics of a(2,3)-linked thiosialosides. These compounds were biologically evaluated as inhibitors of rotaviral infection using an in vitro neutralisation assay. The results suggest that these lactose-based sialylmimetics are not inhibitors of the rhesus rotavirus strain; however, they do exhibit modest inhibition of the human (Wa) strain, presumably through inhibition of the rotaviral adhesion process. | |
dc.description.peerreviewed | Yes | |
dc.description.publicationstatus | Yes | |
dc.language | English | |
dc.language.iso | eng | |
dc.publisher | Pergamon Press | |
dc.publisher.place | Oxford, UK | |
dc.publisher.uri | http://www.elsevier.com/wps/find/journaldescription.cws_home/129/description#description | |
dc.relation.ispartofstudentpublication | N | |
dc.relation.ispartofpagefrom | 739 | |
dc.relation.ispartofpageto | 757 | |
dc.relation.ispartofjournal | Bioorganic & Medicinal Chemistry | |
dc.relation.ispartofvolume | 14 | |
dc.rights.retention | Y | |
dc.subject.fieldofresearch | Medicinal and biomolecular chemistry | |
dc.subject.fieldofresearch | Organic chemistry | |
dc.subject.fieldofresearch | Pharmacology and pharmaceutical sciences | |
dc.subject.fieldofresearch | Biochemistry and cell biology | |
dc.subject.fieldofresearchcode | 3404 | |
dc.subject.fieldofresearchcode | 3405 | |
dc.subject.fieldofresearchcode | 3214 | |
dc.subject.fieldofresearchcode | 3101 | |
dc.title | The synthesis and biological evaluation of lactose-based sialylmimetics as inhibitors of rotaviral infection | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dc.type.code | C - Journal Articles | |
gro.faculty | Office of the Snr Dep Vice Chancellor, Institute for Glycomics | |
gro.date.issued | 2006 | |
gro.hasfulltext | No Full Text | |
gro.griffith.author | von Itzstein, Mark | |
gro.griffith.author | Kiefel, Milton | |