Unsaturated N-acetyl-D-glycosaminuronic acid glycosides as inhibitors of influenza virus sialidase

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Title Unsaturated N-acetyl-D-glycosaminuronic acid glycosides as inhibitors of influenza virus sialidase
Author Mann, Maretta; Islam, Tasneem; Dyason, Jeffrey Clifford; Florio, Pas; Trower, Carolyn J.; Thomson, Robin Joy; von Itzstein, Mark
Journal Name Glycoconjugate Journal
Year Published 2006
Place of publication US
Publisher Springer
Abstract The threat of pandemic influenza is a significant concern of governments worldwide. There is a very limited and relatively expensive armament to tackle such a pandemic should it occur. This fact provides much impetus to the scientific community for the discovery of new and less expensive anti-influenza drugs. Our longstanding interest in the inhibition of influenza virus sialidase, coupled with the development of simple carbohydrates that mimic an unsaturated derivative of the enzyme's naturally-occurring ligand, N-acetylneuraminic acid, has led us to investigate the development of influenza virus sialidase inhibitors based on these mimetics. We have successfully prepared a range of these compounds, in good yield, from the relatively inexpensive carbohydrate N-acetylglucosamine utilising a short synthetic procedure. We have employed a sialidase inhibition assay for biological evaluation of the target compounds and to our delight these mimetics have displayed significant inhibition of influenza virus sialidase.
Peer Reviewed Yes
Published Yes
Alternative URI http://dx.doi.org/10.1007/s10719-006-5445-9
Volume 23
Page from 127
Page to 133
ISSN 0282-0080
Date Accessioned 2007-02-23
Date Available 2010-08-26T07:38:28Z
Language en_AU
Research Centre Institute for Glycomics
Faculty Institute for Glycomics
Subject PRE2009-Biological and Medical Chemistry; PRE2009-Organic Chemical Synthesis
URI http://hdl.handle.net/10072/13718
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1

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