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dc.contributor.authorPlebanski, Magdalena
dc.contributor.authorLopez, Ester
dc.contributor.authorProudfoot, Owen
dc.contributor.authorCooke, Brian M
dc.contributor.authorvon Itzstein, Mark
dc.contributor.authorCoppel, Ross L
dc.date.accessioned2017-05-03T11:05:46Z
dc.date.available2017-05-03T11:05:46Z
dc.date.issued2006
dc.date.modified2009-10-19T05:25:12Z
dc.identifier.issn1046-2023
dc.identifier.doi10.1016/j.ymeth.2006.05.021
dc.identifier.urihttp://hdl.handle.net/10072/13722
dc.description.abstractHerein, we analyze in general the current vaccine market and identify potential factors driving and modulating supply and demand for vaccines. An emphasis is placed on changes in regulation in the last 20 years which have led to increased indirect costs of production, and which can create a barrier against the timely use of technological advances to reduce direct costs. Other defining industry characteristics, such as firm numbers and sizes, cost and pricing strategies, nature extent and impact of Government involvement and international regulation are noted. These considerations, far from being removed from basic vaccine research, influence its ability to achieve aims that can be then progressed into effective vaccine products. We discuss specifically the development of particulate vaccines against malaria, a major lethal disease and health problem prevalent in Africa, including some key economic and methodological challenges and opportunities. We note some practical issues blocking the development of effective particulate vaccines for the Third World, mainly driven by the regulatory spiral noted above.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherAcademic Press
dc.publisher.placeUnited States
dc.publisher.urihttp://www.elsevier.com/wps/find/journaldescription.cws_home/622914/description#description
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom77
dc.relation.ispartofpageto85
dc.relation.ispartofjournalMethods
dc.relation.ispartofvolume40
dc.rights.retentionY
dc.subject.fieldofresearchClinical sciences
dc.subject.fieldofresearchcode3202
dc.titleEconomic and practical challenges to the formulation of vaccines against endemic infectious diseases such as malaria
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2006
gro.hasfulltextNo Full Text
gro.griffith.authorvon Itzstein, Mark


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