Identification of a novel glycosyltransferase involved in LOS biosynthesis of Moraxella catarrhalis
Author(s)
Wilson, Jennifer C
Collins, Patrick M
Klipic, Zoran
Grice, I Darren
Peak, Ian R
Year published
2006
Metadata
Show full item recordAbstract
Moraxella catarrhalis is an important human mucosal pathogen that contributes to otitis media in infants and exacerbates conditions such as chronic obstructive pulmonary disease in the elderly. This study describes the identification of a novel gene, lgt5 that encodes a glycosyltransferase involved in the LOS biosynthesis of M. catarrhalis. Analysis of NMR data of LOS-derived oligosaccharide from a Serotype A lgt5 mutant strain of M. catarrhalis indicate that lgt5 encodes an a-(1?4)-galactosyltransferase.Moraxella catarrhalis is an important human mucosal pathogen that contributes to otitis media in infants and exacerbates conditions such as chronic obstructive pulmonary disease in the elderly. This study describes the identification of a novel gene, lgt5 that encodes a glycosyltransferase involved in the LOS biosynthesis of M. catarrhalis. Analysis of NMR data of LOS-derived oligosaccharide from a Serotype A lgt5 mutant strain of M. catarrhalis indicate that lgt5 encodes an a-(1?4)-galactosyltransferase.
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Journal Title
Carbohydrate Research
Volume
341
Publisher URI
Copyright Statement
© 2006 Elsevier. Please refer to the journal's website for access to the definitive, published version.
Subject
Medicinal and biomolecular chemistry
Organic chemistry
Biochemistry and cell biology