Identification of a novel glycosyltransferase involved in LOS biosynthesis of Moraxella catarrhalis

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Title Identification of a novel glycosyltransferase involved in LOS biosynthesis of Moraxella catarrhalis
Author Wilson, Jenny; Collins, Patrick; Klipic, Zoran; Grice, Darren; Peak, Ian
Journal Name Carbohydrate Research
Year Published 2006
Place of publication United Kingdom
Publisher Pergamon
Abstract Moraxella catarrhalis is an important human mucosal pathogen that contributes to otitis media in infants and exacerbates conditions such as chronic obstructive pulmonary disease in the elderly. This study describes the identification of a novel gene, lgt5 that encodes a glycosyltransferase involved in the LOS biosynthesis of M. catarrhalis. Analysis of NMR data of LOS-derived oligosaccharide from a Serotype A lgt5 mutant strain of M. catarrhalis indicate that lgt5 encodes an α-(1→4)-galactosyltransferase.
Peer Reviewed Yes
Published Yes
Publisher URI http://www.elsevier.com/wps/find/journaldescription.cws_home/424829/description#description
Alternative URI http://dx.doi.org/10.1016/j.carres.2006.07.009
Copyright Statement Copyright 2006 Elsevier. Please refer to the journal's website for access to the definitive, published version.
Volume 341
Page from 2600
Page to 2606
ISSN 0008-6215
Date Accessioned 2007-03-15
Date Available 2012-02-10T01:11:48Z
Language en_US
Research Centre Institute for Glycomics
Faculty Institute for Glycomics
Subject PRE2009-Enzymes; PRE2009-Microbiology
URI http://hdl.handle.net/10072/13723
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1

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