Swimming behaviour and post-swimming activity in Vitamin D receptor knockout mice

There are no files associated with this record.

Title Swimming behaviour and post-swimming activity in Vitamin D receptor knockout mice
Author Burne, Thomas Henry Johnston; Johnston, Amy Nicole Burne; McGrath, John J.; Mackay-Sim, Alan
Journal Name Brain Research Bulletin
Year Published 2006
Place of publication London
Publisher Elsevier
Abstract Animal experiments have shown that Vitamin D plays a role in both brain development and adult brain function. The adult Vitamin D receptor null mutant mouse (VDR -/-) is reported to be less active and more anxious than wild-type litter mate controls and to have poor swimming ability. However, an "anxious" behavioural phenotype is inferred from differences in locomotor behaviour. This is a general problem in behavioural phenotyping where a neurological phenotype is inferred from changes in locomotion which will be affected by non-neurological factors, such as muscle fatigue. In this study of VDR -/-, we conducted a detailed examination of one form of motor behaviour, swimming, compared to wildtype littermate controls. Swimming was assessed using a forced swim test, a laneway swimming test and a watermaze test using a visible platform. Post-swimming activity was assessed by comparing grooming and rearing behaviour before, and 5min after, the forced swimming test. We replicated previous findings in which VDR -/- mice demonstrate more sinking episodes than wildtype controls in the forced swim test but they were similar to controls in the time taken to swim a 1m laneway, and in the time taken to reach a visible platform in the watermaze. Thus, the VDR -/- mice were able to swim but were not able to float. Grooming and rearing behaviour of the VDR -/- mice was similar to wildtype controls before the forced swim but the VDR -/- were much less active after the swim compared with wildtype mice which displayed high levels of grooming and rearing. We conclude that VDR -/- mice have muscular and motor impairments that do not affect their ability to swim but significantly alters the ability to float as well as their post-swimming activity. Differences in muscle strength may confound tests of activity that are used to infer an "anxious" phenotype.
Peer Reviewed Yes
Published Yes
Publisher URI http://www.sciencedirect.com/science/journal/03619230
Alternative URI http://dx.doi.org/10.1016/j.brainresbull.2005.10.014
Volume 69
Page from 74
Page to 78
ISSN 0361-9230
Date Accessioned 2006-03-22
Language en_AU
Research Centre Centre for Health Practice Innovation; Eskitis Institute for Drug Discovery
Faculty Eskitis, Inst Cell&Molecular Therapies
Subject PRE2009-Central Nervous System
URI http://hdl.handle.net/10072/13864
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1

Show simple item record

Griffith University copyright notice