The role of vascular and hormonal genes in migraine susceptibility.

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Title The role of vascular and hormonal genes in migraine susceptibility.
Author Colson, Natalie Jane; Lea, Rodney Arthur; Quinlan, Sharon Anne; Griffiths, Lyn
Journal Name Molecular Genetics and Metabolism
Editor Richard R B McCabe and L L McCabe
Year Published 2006
Place of publication United States
Publisher Elsevier
Abstract Migraine is a primary headache disorder that involves both genetic and environmental components. Migraine is considered to be a polygenic disorder with a number of susceptibility genes having a minor but nonetheless significant impact on susceptibility. Migraine candidate gene studies have concentrated mainly on genes involved in neurotransmitter pathways, however evidence also exists for a role for alterations in vascular and hormonal function in migraine susceptibility. We present here a mini-review of genetic studies, investigating the potential role of vascular and hormonal gene variants, and discuss how vascular and hormonal dysfunction may impact on migraine susceptibility. We propose that the potential role of vascular and hormonal genes in this disorder warrants further investigation.
Peer Reviewed Yes
Published Yes
Publisher URI http://www.elsevier.com/locate/ymgme
Alternative URI http://dx.doi.org/10.1016/j.ymgme.2005.11.013
Volume 88
Edition 2006
Page from 107
Page to 113
ISSN 1096-7192
Date Accessioned 2007-04-12
Language en_AU
Research Centre Griffith Health Institute
Faculty Griffith Health Faculty
Subject PRE2009-Neurogenetics
URI http://hdl.handle.net/10072/14067
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1

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