Antimicrobial peptides, exercise and innate mucosal immunity

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Title Antimicrobial peptides, exercise and innate mucosal immunity
Author West, Nic; Pyne, David B.; Renshaw, Gillian Mary Claire; Cripps, Allan W
Journal Name FEMS Immunology and Medical Microbiology
Editor Alex van Belkum
Year Published 2006
Place of publication Netherlands
Publisher Elsevier BV
Abstract Recombinant exotoxin A (rEPA) from Pseudomonas aeruginosa conjugated to Vibrio cholerae O1 serotype-specific polysaccharides (mono-, di- and hexasaccharide) were immunogenic in mice. Monosaccharide conjugates boosted the humoral responses to the hexasaccharide conjugates. Prior exposure to purified Ogawa lipopolysaccharide (LPS) enabled contra-serotype hexasaccharide conjugates to boost the vibriocidal response, but Inaba LPS did not prime for an enhanced vibriocidal response by a contra-serotype conjugate. Prior exposure to the carrier, and priming B cells with the LPS of either serotype, resulted in enhanced vibriocidal titers if the Ogawa hexasaccharides were used, but a diminished response to the Inaba LPS. These studies demonstrate that the 'functional' B cell epitopes on the LPS differ from those of the neoglycoconjugates and that the order of immunization and the serotype of the boosting conjugate can influence the epitope specificity and function of the antisera.
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Copyright Statement Copyright 2006 Elsevier. This is the author-manuscript version of this paper. Reproduced in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.
Volume 48
Page from 293
Page to 304
ISSN 0928-8244
Date Accessioned 2007-01-31
Language en_AU
Research Centre Menzies Health Institute Qld; Heart Foundation Research Centre; Molecular Basis of Disease
Faculty Griffith Health Faculty
Subject PRE2009-Medical and Health Sciences
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1

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