Lower limb vasodilatory capacity is not reduced in patients with moderate COPD

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Title Lower limb vasodilatory capacity is not reduced in patients with moderate COPD
Author Sabapathy, Surendran; Awater, Marc F; Schneider, Donald Anthony; Kingsley, Rebecca Anne; Hopman, Maria T E; Morris, Norman
Journal Name International Journal of Chronic Obstructive Pulmonary Disease
Editor Richard Russell
Year Published 2006
Place of publication New Zealand
Publisher Dove Medical Press
Abstract We compared exercise capacity (peak O2 uptake) and lower limb vasodilatory capacity in 9 patients with moderate chronic obstructive pulmonary disease (COPD) (forced expiratory volume in 1 s = 55 ± 3 % predicted) and 9 age-matched healthy control subjects. Peak O2 uptake was measured via open circuit spirometry during incremental cycling. Calf blood flow (CBF) measurements were obtained at rest and after 5 minutes of ischemia using venous occlusion plethysmography. While peak O2 uptake was significantly lower in the COPD patients (15.8 ± 3.5 mL/min/kg) compared to the control group (25.2 ± 3.5 mL/kg/min), there were no significant differences between groups in peak CBF or peak calf conductance measured 7 s post-ischemia. peak O2 uptake was significantly correlated with peak CBF and peak conductance in the control group, whereas there was no significant relationship found between these variables in the COPD group. However, the rate of decay in blood flow following ischemia was significantly slower (p<0.05) for the COPD group (-0.036 ± 0.005 mL/100 mL/min/s) when compared to controls (-0.048 ± 0.015 mL/100 mL/min/s). The results suggest that the lower peak exercise capacity in patients with moderate COPD is not related to a loss in leg vasodilatory capacity.
Peer Reviewed Yes
Published Yes
Publisher URI http://www.dovepress.com/lower-limb-vasodilatory-capacity-is-not-reduced-in-patients-with-moder-a434
Alternative URI http://www.dovepress.com/articles.php?journal_id=6
Volume 1
Issue Number 1
Page from 73
Page to 81
ISSN 1176-9106
Date Accessioned 2006-06-22
Date Available 2009-01-20T06:12:32Z
Language en_AU
Research Centre Heart Foundation Research Centre; Griffith Health Institute
Faculty Griffith Health Faculty
Subject PRE2009-Exercise Physiology; PRE2009-Respiratory Diseases; PRE2009-Systems Physiology
URI http://hdl.handle.net/10072/14260
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1

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