A modified, naturally-derived scaffold as a multifunctional, cell conductive and inductive framework with promising use in tissue bioregeneration

Abstract

A Modified, Naturally-Derived Scaffold as a Multifunctional, Cell Conductive and Inductive Framework with Promising Use In Tissue Bioregeneration.

P.A. McDonnell, Genomics Research Centre, School of Biomolecular and Biomedical Sciences, Griffith University, Nathan, Queensland, Australia 4111.

Our modified naturally-derived scaffold avoids the cell propagation and survivability problems faced by many current scaffolds in that it mimics a host structure that facilitates all mammalian tissue growth. The commercial target is the U.S biocompatible materials market estimated at $8.2 billion in sales in 2003 and forecast to grow by 7-8% per annum to reach some $12 billion in sales by 2008.

We have employed a new approach to 3D tissue growth by the use of a modified, naturally-derived material in the construction of a unique 3D scaffold that will support the growth of a variety of cell lines. To date, the cell lines grown successfully on the scaffold include a range of mammalian (human and mouse) cell lines of neural, bone, cardiomyocyte, epithelial and intestinal mucosal cell and stem cell origins. The abundance and structural properties of the scaffold and its potential as a multifunctional, cell conductive and inductive framework indicate a promising new source of scaffold use in for tissue regeneration studies in both the in vitro and in vivo settings.

The scaffold exhibits the important characteristics that must be considered when producing and applying new bioengineering technologies in the clinical setting, namely the scaffold possesses: ·A network of interconnecting pores of appropriate scale to favour tissue integration and microvascularisation of new blood vessels. ·Controlled biodegradability or bioresorbability. ·A surface chemistry and topography that favor cellular attachment, differentiation and proliferation. ·Adequate mechanical properties to match the intended site of implantation and handling. ·Low immunogenicity. ·The capability of being easily manipulated into various shapes, sizes.

The presentation will address the latest results of current studies.

Griffith University seeks a collaborative arrangement with an industrial partner possessing the interest and capability to work with us to develop the technology to its full potential in accordance with their commercial requirements.