Allelic variation investigation of the estrogen receptor within an Australian multiple sclerosis population

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Title Allelic variation investigation of the estrogen receptor within an Australian multiple sclerosis population
Author Tajouri, Lotfi; Fernandez, Francesca; Tajouri, Sophie; Detriche, Geraldine; Szvetko, Attila Laszlo; Colson, Natalie Jane; Csurhes, Peter; Pender, Michael P.; Griffiths, Lyn
Journal Name Journal of the Neurlogical Sciences
Editor Dr. Robert P Lisak
Year Published 2007
Place of publication Netherlands
Publisher Elsevier B.V.
Abstract Multiple Sclerosis (MS) is a central nervous system (CNS) chronic inflammatory demyelinating disease leading to various neurological disabilities. The disorder is more prevalent for women with a ratio of 3:2 female to male. Objectives: To investigate variation within the estrogen receptor 1 (ESR1) polymorphism gene in an Australian MS case-control population using two intragenic restriction fragment length polymorphisms; the G594A located in exon 8 detected with the BtgI restriction enzyme and T938C located in intron 1, detected with PvuII. One hundred and ten Australian MS patients were studied, with patients classified clinically as Relapsing Remitting MS (RR-MS), Secondary Progressive MS (SP-MS) or Primary Progressive MS (PP-MS). Also, 110 age, sex and ethnicity matched controls were investigated as a comparative group. No significant difference in the allelic distribution frequency was found between the case and control groups for the ESR1 PvuII (P=0.50) and Btg1 (P=0.45) marker. Our results do not support a role for these two ESR1 markers in multiple sclerosis susceptibility, however other markers within ESR1 should not be excluded for potential involvement in the disorder.
Peer Reviewed Yes
Published Yes
Publisher URI http://www.elsevier.com/wps/find/journaldescription.cws_home/506078/description#description
Alternative URI http://dx.doi.org/10.1016/j.jns.2006.09.018
Copyright Statement Copyright 2007 Elsevier. Please refer to the journal's website for access to the definitive, published version.
Volume 252
Issue Number 1
Page from 9
Page to 12
ISSN 0022-510X
Date Accessioned 2007-01-08
Language en_AU
Research Centre Griffith Health Institute
Faculty Griffith Health Faculty
Subject PRE2009-Neurogenetics
URI http://hdl.handle.net/10072/14981
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1

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