Coronin 3 involvement in F-actin-dependent processes at the cell cortex

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Title Coronin 3 involvement in F-actin-dependent processes at the cell cortex
Author Rosentreter, Andre; Hofmann, Andreas; Xavier, Charles-Peter; Stumpf, Maria; Noegel, Angelika A.; Clemen, Christoph S.
Journal Name Experimental Cell Research
Year Published 2007
Place of publication United States
Publisher Academic Press
Abstract The actin interaction of coronin 3 has been mainly documented by in vitro experiments. Here, we discuss coronin 3 properties in the light of new structural information and focus on assays that reflect in vivo roles of coronin 3 and its impact on F-actin-associated functions. Using GFP-tagged coronin 3 fusion proteins and RNAi silencing we show that coronin 3 has roles in wound healing, protrusion formation, cell proliferation, cytokinesis, endocytosis, axonal growth, and secretion. During formation of cell protrusions actin accumulation precedes the focal enrichment of coronin 3 suggesting a role for coronin 3 in events that follow the initial F-actin assembly. Moreover, we show that coronin 3 similar to other coronins interacts with the Arp2/3-complex and cofilin indicating that this family in general is involved in regulating Arp2/3-mediated events.
Peer Reviewed Yes
Published Yes
Alternative URI http://dx.doi.org/10.1016/j.yexcr.2006.12.015
Copyright Statement Copyright 2007 Elsevier. This is the author-manuscript version of this paper. Reproduced in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.
Volume 313
Page from 878
Page to 895
ISSN 0014-4827
Date Accessioned 2007-02-07
Date Available 2015-05-04T22:04:06Z
Language en_US
Research Centre Eskitis Institute for Drug Discovery
Faculty Faculty of Science, Environment, Engineering and Technology
Subject PRE2009-Cell Development (incl. Cell Division and Apoptosis)
URI http://hdl.handle.net/10072/14982
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1

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