dc.contributor.author | Fraenkel, D | |
dc.contributor.author | Rickard, C | |
dc.contributor.author | Thomas, P | |
dc.contributor.author | Faoagali, J | |
dc.contributor.author | George, N | |
dc.contributor.author | Ware, R | |
dc.date.accessioned | 2017-05-03T15:25:04Z | |
dc.date.available | 2017-05-03T15:25:04Z | |
dc.date.issued | 2006 | |
dc.date.modified | 2009-01-12T06:23:17Z | |
dc.identifier.issn | 0090-3493 | |
dc.identifier.uri | http://hdl.handle.net/10072/15306 | |
dc.description.abstract | OBJECTIVE: Central venous catheters are the predominant cause of nosocomial bacteremia; however, the effectiveness of different antimicrobial central venous catheters remains uncertain. We compared the infection rate of silver-platinum-carbon (SPC)-impregnated catheters with rifampicin-minocycline (RM)-coated catheters. DESIGN: A large, single-center, prospective randomized study. SETTING: Twenty-two-bed adult general intensive care unit in a large tertiary metropolitan hospital in Brisbane, Australia (2000-2001). PATIENTS: Consecutive series of all central venous catheterizations in intensive care unit patients. INTERVENTIONS: Randomization, concealment, and blinding were carefully performed. Catheter insertion and care were performed according to published guidelines. Blood cultures were taken at central venous catheter removal, and catheter-tip cultures were performed by both roll-plate and sonication techniques. Pulsed field gel electrophoresis was used to establish shared clonal origin for matched isolates. MEASUREMENTS AND MAIN RESULTS: Central venous catheter colonization and catheter-related bloodstream infection were determined with a blinded technique using the evaluation of the extensive microbiological and clinical data collected and a rigorous classification system. Six hundred forty-six central venous catheters (RM 319, SPC 327) were inserted, and 574 (89%) were microbiologically evaluable. Colonization rates were lower for the RM catheters than SPC catheters (25 of 280, 8.9%; 43 of 294, 14.6%; p=.039). A Kaplan-Meier analysis that included catheter time in situ did not quite achieve statistical significance (p=.055). Catheter-related bloodstream infection was infrequent for both catheter-types (RM 4, 1.4%; SPC 5, 1.7%). CONCLUSIONS: The SPC catheter is a clinically effective antimicrobial catheter; however, the RM catheter had a lower colonization rate. Both catheter types had low rates of catheter-related bloodstream infection. These results indicate that future studies will require similar rigorous methodology and thousands of central venous catheters to demonstrate differences in catheter-related bloodstream infection rates. | |
dc.description.peerreviewed | Yes | |
dc.description.publicationstatus | Yes | |
dc.language | English | |
dc.language.iso | eng | |
dc.publisher | Lippincott Wilkins & Williams | |
dc.publisher.place | USA | |
dc.publisher.uri | http://www.ccmjournal.org/pt/re/ccm/home.htm;jsessionid=HcfB2x2dY5dhlGyrJzGL12r2bdSTs51cKZBcnJS6Lp6668MTnGY7!1071114923!181195629!8091!-1 | |
dc.relation.ispartofstudentpublication | N | |
dc.relation.ispartofpagefrom | 668 | |
dc.relation.ispartofpageto | 675 | |
dc.relation.ispartofissue | 3 | |
dc.relation.ispartofjournal | Critical Care Medicine | |
dc.relation.ispartofvolume | 34 | |
dc.rights.retention | N | |
dc.subject.fieldofresearch | Clinical sciences | |
dc.subject.fieldofresearch | Nursing | |
dc.subject.fieldofresearchcode | 3202 | |
dc.subject.fieldofresearchcode | 4205 | |
dc.title | A prospective randomized trial of rifampicin-minocycline coated and silver-platinum-carbon impregnated central venous catheters | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dc.type.code | C - Journal Articles | |
gro.rights.copyright | © 2006 Lippincott, Williams & Wilkins. Self-archiving of the author-manuscript version is not yet supported by this publisher. Please use the hypertext link above to access the journal's website or contact the author for more information. | |
gro.date.issued | 2006 | |
gro.hasfulltext | No Full Text | |
gro.griffith.author | Ware, Robert | |