KATP channels and myocardial preconditioning: an update.

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Title KATP channels and myocardial preconditioning: an update.
Author Gross, Garrett J.; Peart, Jason Nigel John
Journal Name American Journal of Physiology : Heart and Circulatory Physiology
Year Published 2003
Place of publication United States
Publisher American Physiological Society
Abstract Ischemic or myocardial preconditioning (IPC) is a phenomenon whereby brief periods of ischemia have been shown to protect the myocardium against a more sustained ischemic insult. The result of IPC may be manifest as a marked reduction in infarct size, myocardial stunning, or incidence of cardiac arrhythmias. Whereas many endogenous neurotransmitters, peptides, and hormones have been proposed to play a role in the signal transduction pathways mediating the cardioprotective effect of IPC, nearly universal evidence indicates the involvement of the ATP-sensitive potassium (KATP) channel. Initial evidence suggested that the surface or sarcolemmal KATP (sarcKATP) channel triggered or mediated the cardioprotective effects of IPC; however, more recent findings have suggested a major role for a mitochondrial site or possibly a mitochondrial KATP channel (mitoKATP). This review presents evidence that supports a role for these two channels as a trigger and/or downstream mediator in the phenomenon of IPC or pharmacologically induced PC as well as recent evidence that suggests the involvement of a mitochondrial calcium-activated potassium (mitoKca) channel or the electron transport chain in mediating the beneficial effects of IPC or pharmacologically induced PC.
Peer Reviewed Yes
Published Yes
Publisher URI http://ajpheart.physiology.org/content/285/3/H921
Copyright Statement Self-archiving of the author-manuscript version is not yet supported by this journal. Please refer to the journal link for access to the definitive, published version or contact the author[s] for more information.
Volume 285
Page from 921
Page to 930
ISSN 0363-6135
Date Accessioned 2006-07-26
Date Available 2015-02-04T04:25:28Z
Language en_US
Research Centre Menzies Health Institute Qld; Heart Foundation Research Centre
Faculty Other
Subject PRE2009-Clinical Pharmacology and Therapeutics
URI http://hdl.handle.net/10072/15479
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1x

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