dc.contributor.author | N. Peart, Jason | |
dc.contributor.author | J. Gross, Garrett | |
dc.date.accessioned | 2017-05-03T13:03:40Z | |
dc.date.available | 2017-05-03T13:03:40Z | |
dc.date.issued | 2003 | |
dc.identifier.issn | 03636135 | |
dc.identifier.uri | http://hdl.handle.net/10072/15480 | |
dc.description.abstract | The relative roles of free-radical production, mitochondrial ATP-sensitive K+ (mitoKATP) channels and possible receptor cross-talk in both opioid and adenosine A1 receptor (A1AR) mediated protection were assessed in a rat model of myocardial infarction. Sprague-Dawley rats were subjected to 30 min of occlusion and 90 min of reperfusion. The untreated rats exhibited an infarct of 58.8 ᠲ.9% [infarct size (IS)/area at risk (AAR), %] at the end of reperfusion. Pretreatment with either the nonselective opioid receptor agonist morphine or the selective A1AR agonist 2-chloro-cyclopentyladenosine (CCPA) dramatically reduced IS/AAR to 41.1 ᠲ.2% and 37.9 ᠵ.5%, respectively (P < 0.05). Protection afforded by either morphine or CCPA was abolished by the reactive oxygen species scavenger N-(2-mercaptopropionyl)glycine or the mitoKATP channel blocker 5-hydroxydecanoate. Both morphine- and CCPA-mediated protection were attenuated by the selective A1AR antagonist 1,3-dipropyl-8-cyclopentylxanthine and the selective d1-opioid receptor (DOR) antagonist 7-benzylidenealtrexone. Simultaneous administration of morphine and CCPA failed to enhance the infarct-sparing effect of either agonist alone. These data suggest that both DOR and A1AR-mediated cardioprotection are mitoKATP and reactive oxygen species dependent. Furthermore, these data suggest that there are converging pathways and/or receptor cross-talk between A1AR- and DOR-mediated cardioprotection. | |
dc.description.peerreviewed | Yes | |
dc.description.publicationstatus | Yes | |
dc.language | English | |
dc.language.iso | eng | |
dc.publisher | American Physiological Society | |
dc.publisher.place | United States | |
dc.publisher.uri | http://ajpheart.physiology.org/content/285/1/H81 | |
dc.relation.ispartofpagefrom | 81 | |
dc.relation.ispartofpageto | 89 | |
dc.relation.ispartofjournal | American Journal of Physiology: Heart and Circulatory Physiology | |
dc.relation.ispartofvolume | 285 | |
dc.subject.fieldofresearch | Zoology | |
dc.subject.fieldofresearch | Medical physiology | |
dc.subject.fieldofresearch | Cardiovascular medicine and haematology | |
dc.subject.fieldofresearchcode | 3109 | |
dc.subject.fieldofresearchcode | 3208 | |
dc.subject.fieldofresearchcode | 3201 | |
dc.title | Adenosine and opioid receptor-mediated cardioprotection in the rat: evidence for cross-talk between receptors. | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dc.type.code | C - Journal Articles | |
gro.rights.copyright | Self-archiving of the author-manuscript version is not yet supported by this journal. Please refer to the journal link for access to the definitive, published version or contact the author[s] for more information. | |
gro.date.issued | 2015-02-05T03:42:59Z | |
gro.hasfulltext | No Full Text | |
gro.griffith.author | Peart, Jason N. | |