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dc.contributor.authorN. Peart, Jason
dc.contributor.authorJ. Gross, Garrett
dc.date.accessioned2017-05-03T13:03:40Z
dc.date.available2017-05-03T13:03:40Z
dc.date.issued2003
dc.identifier.issn03636135
dc.identifier.urihttp://hdl.handle.net/10072/15480
dc.description.abstractThe relative roles of free-radical production, mitochondrial ATP-sensitive K+ (mitoKATP) channels and possible receptor cross-talk in both opioid and adenosine A1 receptor (A1AR) mediated protection were assessed in a rat model of myocardial infarction. Sprague-Dawley rats were subjected to 30 min of occlusion and 90 min of reperfusion. The untreated rats exhibited an infarct of 58.8 ᠲ.9% [infarct size (IS)/area at risk (AAR), %] at the end of reperfusion. Pretreatment with either the nonselective opioid receptor agonist morphine or the selective A1AR agonist 2-chloro-cyclopentyladenosine (CCPA) dramatically reduced IS/AAR to 41.1 ᠲ.2% and 37.9 ᠵ.5%, respectively (P < 0.05). Protection afforded by either morphine or CCPA was abolished by the reactive oxygen species scavenger N-(2-mercaptopropionyl)glycine or the mitoKATP channel blocker 5-hydroxydecanoate. Both morphine- and CCPA-mediated protection were attenuated by the selective A1AR antagonist 1,3-dipropyl-8-cyclopentylxanthine and the selective d1-opioid receptor (DOR) antagonist 7-benzylidenealtrexone. Simultaneous administration of morphine and CCPA failed to enhance the infarct-sparing effect of either agonist alone. These data suggest that both DOR and A1AR-mediated cardioprotection are mitoKATP and reactive oxygen species dependent. Furthermore, these data suggest that there are converging pathways and/or receptor cross-talk between A1AR- and DOR-mediated cardioprotection.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherAmerican Physiological Society
dc.publisher.placeUnited States
dc.publisher.urihttp://ajpheart.physiology.org/content/285/1/H81
dc.relation.ispartofpagefrom81
dc.relation.ispartofpageto89
dc.relation.ispartofjournalAmerican Journal of Physiology: Heart and Circulatory Physiology
dc.relation.ispartofvolume285
dc.subject.fieldofresearchZoology
dc.subject.fieldofresearchMedical physiology
dc.subject.fieldofresearchCardiovascular medicine and haematology
dc.subject.fieldofresearchcode3109
dc.subject.fieldofresearchcode3208
dc.subject.fieldofresearchcode3201
dc.titleAdenosine and opioid receptor-mediated cardioprotection in the rat: evidence for cross-talk between receptors.
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.rights.copyrightSelf-archiving of the author-manuscript version is not yet supported by this journal. Please refer to the journal link for access to the definitive, published version or contact the author[s] for more information.
gro.date.issued2015-02-05T03:42:59Z
gro.hasfulltextNo Full Text
gro.griffith.authorPeart, Jason N.


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