dc.contributor.author | Berners-Price, SJ | |
dc.contributor.author | Bowen, RJ | |
dc.contributor.author | Galettis, P | |
dc.contributor.author | Healy, PC | |
dc.contributor.author | McKeage, MJ | |
dc.date.accessioned | 2017-09-25T00:47:51Z | |
dc.date.available | 2017-09-25T00:47:51Z | |
dc.date.issued | 1999 | |
dc.date.modified | 2009-08-25T03:44:36Z | |
dc.identifier.issn | 0010-8545 | |
dc.identifier.doi | 10.1016/S0010-8545(99)00039-9 | |
dc.identifier.uri | http://hdl.handle.net/10072/15550 | |
dc.description.abstract | The 1:2 adducts of Ag(I) and Au(I) with 1,2-bis(di-n-pyridylphosphino)ethane (dnpype) for n=2, 3 and 4 have been synthesised and solution properties characterised by multinuclear NMR spectroscopy. The complexes are hydrophilic analogs of the lipophilic Au(I) antitumour complex [Au(dppe)2]+ and the degree of hydrophilicity depends critically on the position of the N atom in the pyridyl ring. The complexes of d3pype and d4pype are simple monomeric [M(d3pype)2]+ and [M(d4pype)2]+ species which have a much higher water solubility than the 2-pyridyl complexes which crystallise in the solid state as dimeric [{M(d2pype)2}2]2+. In solution these 1:2 M:d2pype species exist as equilibrium mixtures of monomeric, dimeric and trimeric (Ag) or tetrameric (Au) clusters. The Au(I) and Ag(I)pyridyl phosphine complexes have been evaluated for antitumour activity against a panel of cultured human ovarian carcinoma cell lines. The results show both potent and selective activity for the compounds with IC50 values ranging from 0.18 to 1500 卮 There is a correlation between the degree of antitumour selectivity and the octanol/water partition coefficients with the greatest selectivity (500-fold range) found for the most hydrophilic complex [Au(d4pype)2]Cl. Clinical development of the parent compound [Au(dppe)2]+ was halted by liver toxicity and the hydrophilic pyridylphosphine analogs are significantly less toxic than [Au(dppe)2]+ when exposed to isolated rat hepatocytes. Convenient synthetic routes to the bidentate pyridyl phosphines d2pype, d3pype and d4pype are also described. | |
dc.description.peerreviewed | Yes | |
dc.description.publicationstatus | Yes | |
dc.language | English | |
dc.language.iso | eng | |
dc.publisher | Elsevier Science | |
dc.publisher.place | Switzerland | |
dc.publisher.uri | http://www.sciencedirect.com/science/journal/00108545 | |
dc.relation.ispartofpagefrom | 823 | |
dc.relation.ispartofpageto | 836 | |
dc.relation.ispartofjournal | Coordination Chemistry Reviews | |
dc.relation.ispartofvolume | 185-186 | |
dc.subject.fieldofresearch | Inorganic chemistry | |
dc.subject.fieldofresearch | Physical chemistry | |
dc.subject.fieldofresearch | Other chemical sciences | |
dc.subject.fieldofresearchcode | 3402 | |
dc.subject.fieldofresearchcode | 3406 | |
dc.subject.fieldofresearchcode | 3499 | |
dc.title | Structural and Solution Chemistry of gold(I) and Silver(I) complexes of bidentate pyridyl phosphines: selective antitumour agents | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dc.type.code | C - Journal Articles | |
gro.faculty | Office of the Snr Dep Vice Chancellor, Institute for Glycomics | |
gro.rights.copyright | © 1999 Elsevier. Please refer to the journal's website for access to the definitive, published version. | |
gro.date.issued | 1999 | |
gro.hasfulltext | No Full Text | |
gro.griffith.author | Healy, Peter C. | |
gro.griffith.author | Berners-Price, Sue J. | |