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dc.contributor.authorBerners-Price, SJ
dc.contributor.authorBowen, RJ
dc.contributor.authorGalettis, P
dc.contributor.authorHealy, PC
dc.contributor.authorMcKeage, MJ
dc.date.accessioned2017-09-25T00:47:51Z
dc.date.available2017-09-25T00:47:51Z
dc.date.issued1999
dc.date.modified2009-08-25T03:44:36Z
dc.identifier.issn0010-8545
dc.identifier.doi10.1016/S0010-8545(99)00039-9
dc.identifier.urihttp://hdl.handle.net/10072/15550
dc.description.abstractThe 1:2 adducts of Ag(I) and Au(I) with 1,2-bis(di-n-pyridylphosphino)ethane (dnpype) for n=2, 3 and 4 have been synthesised and solution properties characterised by multinuclear NMR spectroscopy. The complexes are hydrophilic analogs of the lipophilic Au(I) antitumour complex [Au(dppe)2]+ and the degree of hydrophilicity depends critically on the position of the N atom in the pyridyl ring. The complexes of d3pype and d4pype are simple monomeric [M(d3pype)2]+ and [M(d4pype)2]+ species which have a much higher water solubility than the 2-pyridyl complexes which crystallise in the solid state as dimeric [{M(d2pype)2}2]2+. In solution these 1:2 M:d2pype species exist as equilibrium mixtures of monomeric, dimeric and trimeric (Ag) or tetrameric (Au) clusters. The Au(I) and Ag(I)pyridyl phosphine complexes have been evaluated for antitumour activity against a panel of cultured human ovarian carcinoma cell lines. The results show both potent and selective activity for the compounds with IC50 values ranging from 0.18 to 1500 卮 There is a correlation between the degree of antitumour selectivity and the octanol/water partition coefficients with the greatest selectivity (500-fold range) found for the most hydrophilic complex [Au(d4pype)2]Cl. Clinical development of the parent compound [Au(dppe)2]+ was halted by liver toxicity and the hydrophilic pyridylphosphine analogs are significantly less toxic than [Au(dppe)2]+ when exposed to isolated rat hepatocytes. Convenient synthetic routes to the bidentate pyridyl phosphines d2pype, d3pype and d4pype are also described.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier Science
dc.publisher.placeSwitzerland
dc.publisher.urihttp://www.sciencedirect.com/science/journal/00108545
dc.relation.ispartofpagefrom823
dc.relation.ispartofpageto836
dc.relation.ispartofjournalCoordination Chemistry Reviews
dc.relation.ispartofvolume185-186
dc.subject.fieldofresearchInorganic chemistry
dc.subject.fieldofresearchPhysical chemistry
dc.subject.fieldofresearchOther chemical sciences
dc.subject.fieldofresearchcode3402
dc.subject.fieldofresearchcode3406
dc.subject.fieldofresearchcode3499
dc.titleStructural and Solution Chemistry of gold(I) and Silver(I) complexes of bidentate pyridyl phosphines: selective antitumour agents
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.facultyOffice of the Snr Dep Vice Chancellor, Institute for Glycomics
gro.rights.copyright© 1999 Elsevier. Please refer to the journal's website for access to the definitive, published version.
gro.date.issued1999
gro.hasfulltextNo Full Text
gro.griffith.authorHealy, Peter C.
gro.griffith.authorBerners-Price, Sue J.


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