Crystallisation and preliminary crystallographic analysis of recombinant human galectin-1

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Title Crystallisation and preliminary crystallographic analysis of recombinant human galectin-1
Author Scott, Stacy; Scott, Ken; Blanchard, Helen
Journal Name Acta Crystallographica. Section F: Structural Biology and Crystallization Communications
Year Published 2007
Place of publication United Kingdom
Publisher International Union of Crystallography
Abstract Galectin-1 is considered a regulator protein as it is ubiquitously expressed throughout the adult body and is responsible for a broad range of cellular regulatory functions. Interest in galectin-1 from a drug-design perspective is founded on evidence of its over-expression by many cancers, and its immunomodulatory properties. The development of galectin-1-specific inhibitors is a rational approach to the fight against cancer because although galectin-1 induces a plethora of effects, null mice appear normal. X-ray crystallographic structure determination will aid structure-based design of galectin-1 inhibitors. Herein the crystallization and preliminary diffraction analysis of human galectin-1 crystals, generated under six different conditions, is reported. X-ray diffraction data enabled assignment of unit cell parameters for crystals grown under one condition, belonging to a tetragonal crystal system, and definition of another as monoclinic P21, representing two new crystal forms of human galectin-1.
Peer Reviewed Yes
Published Yes
Alternative URI
Volume F63
Page from 967
Page to 971
ISSN 1744-3091
Date Accessioned 2007-11-02
Date Available 2015-01-30T00:42:47Z
Language en_US
Research Centre Institute for Glycomics
Faculty Faculty of Science, Environment, Engineering and Technology
Subject PRE2009-Biological and Medical Chemistry
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1

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