Quality of life compared during pharmacological treatments and clinical monitoring for non-localized prostate cancer: A randomized controlled trial

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Title Quality of life compared during pharmacological treatments and clinical monitoring for non-localized prostate cancer: A randomized controlled trial
Author Green, Heather J; Pakenham, K. I.; Headley, B. C.; Yaxley, J.; Nicol, D. L.; Mactaggart, P. N.; Swanson, C. E.; Watson, R. B.; Gardiner, R A
Journal Name BJU International
Year Published 2004
Place of publication Dublin
Publisher Blackwell Publishing
Abstract OBJECTIVES To investigate the effects of different management strategies for non-localized prostate cancer on men's quality of life and cognitive functioning. PATIENTS, SUBJECTS AND METHODS Men with prostate cancer were randomly assigned to one of four treatment arms: leuprorelin, goserelin, cyproterone acetate (CPA), or close clinical monitoring. In a repeated-measures design, men were assessed before treatment (baseline) and after 6 and 12 months of treatment. A community comparison group of men of the same age with no prostate cancer participated for the same length of time. The men were recruited from public and private urology departments from university teaching hospitals. All those with prostate cancer who were eligible for hormonal therapy had no symptoms requiring immediate therapy. In all, 82 patients were randomized and 62 completed the 1-year study, and of the 20 community participants, 15 completed the study. The main outcome measures were obtained from questionnaires on emotional distress, existential satisfaction, physical function and symptoms, social and role function, subjective cognitive function, and sexual function, combined with standard neuropsychological tests of memory, attention, and executive functions. RESULTS Sexual dysfunction increased for patients on androgen-suppressing therapies, and emotional distress increased in those assigned to CPA or close clinical monitoring. Compared with before treatment there was evidence of an adverse effect of leuprorelin, goserelin, and CPA on cognitive function. Conclusions In deciding the timing of androgen suppression therapy for prostate cancer, consideration should be given to potential adverse effects on quality of life and cognitive function.
Peer Reviewed Yes
Published Yes
Publisher URI http://www.blackwellpublishing.com/
Alternative URI http://dx.doi.org/10.1111/j.1464-410X.2004.04763.x
Copyright Statement Copyright 2004 Blackwell Publishing. This is the author-manuscript version of the paper. Reproduced in accordance with the copyright policy of the publisher. The definitive version is available at www.blackwell-synergy.com
Volume 93
Issue Number 4
Page from 975
Page to 979
ISSN 1464-4096
Date Accessioned 2006-06-09
Language en_AU
Research Centre Behavioural Basis of Health
Faculty Griffith Health Faculty
Subject PRE2009-Biological Psychology (Neuropsychology, Psychopharmacology, Physiologica; PRE2009-Health, Clinical and Counselling Psychology; PRE2009-Surgery
URI http://hdl.handle.net/10072/16906
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1x

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