Health risk assessment of chlorobenzenes in the air of residential houses using probabilistic techniques

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Title Health risk assessment of chlorobenzenes in the air of residential houses using probabilistic techniques
Author Djohan, .; Yu, Jimmy; Connell, Des; Christensen, Elizabeth
Journal Name Journal of Toxicology and Environmental Health. Part A
Editor S. Kacew
Year Published 2007
Place of publication London
Publisher Taylor and Francis
Abstract A human health risk assessment was performed to evaluate the risks due to chlorobenzenes in the air of residential houses. Chlorobenzenes found in the air in the toilets, rooms, and outdoors of three houses in Brisbane, Australia, were sampled by trapping on Tenax TA and analyzed using an automated thermal desorption (ATD)-gas chromatography/mass spectrometry (GC/MS) method. Concentrations of 1,4-dichlorobenzene (1,4-DCB) in the rooms, toilets, and outdoors were used as the exposure concentrations (E), while those in the toilets (μg/m3) were used as the high-exposure concentrations (HE). The exposure concentrations were transformed into exposure doses (EXDE and EXDHE). Dose-response data from the literature for a range of adverse effects in animals were obtained and exposure doses were expressed as human equivalent dose (HED). The HED values were higher than the EXDE and EXDHE values for all adverse effects, and a hazard quotient was calculated that indicated a low level of risk with the high-exposure environment. The lifetime average daily doses (LADDs) for a wide range of adverse effects observed in human case studies were estimated and compared to the doses in the high-exposure (HE) situation. Using the Monte Carlo simulation technique the probabilities of risk quotients higher than unity ranged from 0.02 to 0.26. This evaluation indicated that 1,4-DCB posed low risks to general residents; however, for individuals with susceptible characteristics and exposure to elevated 1,4-DCB, the probability of adverse responses was moderate to high.
Peer Reviewed Yes
Published Yes
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Copyright Statement Copyright 2007 Taylor & Francis. Please refer to the journal's website for access to the definitive, published version.
Volume 70
Page from 1594
Page to 1603
ISSN 1528-7394
Date Accessioned 2007-11-26
Language en_AU
Faculty Faculty of Science, Environment, Engineering and Technology
Subject PRE2009-Biological Sciences; PRE2009-Environmental Chemistry (incl. Atmospheric Chemistry); PRE2009-Environmental Impact Assessment
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1

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