Habbemines A and B, Pyrrolidine Alkaloids with Human δ-Opioid Receptor Binding Affinity from the Leaves of Elaeocarpus habbemensis
Author(s)
Katavic, Peter L
Venables, Debra A
Rali, Topul
Carroll, Anthony R
Griffith University Author(s)
Year published
2007
Metadata
Show full item recordAbstract
The first phytochemical investigation of the Papua New Guinean plant Elaeocarpus habbemensis resulted in the isolation of two new pyrrolidine alkaloids, habbemine A (2) and B (3), as a 1:1 mixture of inseparable diastereomers. The structures of these compounds and their relative configurations were determined by spectroscopic means. An equimolar mixture of habbemine A and B showed human d-opioid receptor binding affinity with an IC50 of 32.1卮The first phytochemical investigation of the Papua New Guinean plant Elaeocarpus habbemensis resulted in the isolation of two new pyrrolidine alkaloids, habbemine A (2) and B (3), as a 1:1 mixture of inseparable diastereomers. The structures of these compounds and their relative configurations were determined by spectroscopic means. An equimolar mixture of habbemine A and B showed human d-opioid receptor binding affinity with an IC50 of 32.1卮
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Journal Title
Journal of Natural Products
Volume
70
Issue
5
Publisher URI
Subject
Chemical sciences
Biological sciences
Biomedical and clinical sciences