Habbemines A and B, Pyrrolidine Alkaloids with Human δ-Opioid Receptor Binding Affinity from the Leaves of Elaeocarpus habbemensis

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Title Habbemines A and B, Pyrrolidine Alkaloids with Human δ-Opioid Receptor Binding Affinity from the Leaves of Elaeocarpus habbemensis
Author Katavic, Peter; Venables, Debra Ann; Rali, Topul; Carroll, Anthony Richard
Journal Name Journal of Natural Products
Editor Douglas Kinghorn
Year Published 2007
Place of publication USA
Publisher American chemical Society
Abstract The first phytochemical investigation of the Papua New Guinean plant Elaeocarpus habbemensis resulted in the isolation of two new pyrrolidine alkaloids, habbemine A (2) and B (3), as a 1:1 mixture of inseparable diastereomers. The structures of these compounds and their relative configurations were determined by spectroscopic means. An equimolar mixture of habbemine A and B showed human δ-opioid receptor binding affinity with an IC50 of 32.1µM.
Peer Reviewed Yes
Published Yes
Publisher URI http://pubs.acs.org/journal/jnprdf
Alternative URI http://dx.doi.org/10.1021/np060577f
Volume 70
Issue Number 5
Page from 866
Page to 868
ISSN 0163-3864
Date Accessioned 2008-02-08
Language en_AU
Research Centre Eskitis Institute for Drug Discovery; Environmental Futures Research Institute
Faculty Faculty of Science, Environment, Engineering and Technology
Subject PRE2009-Organic Chemistry
URI http://hdl.handle.net/10072/17660
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1

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