Association analysis of chromosome 1 migraine candidate genes

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Title Association analysis of chromosome 1 migraine candidate genes
Author Fernandez, Francesca; Curtain, Rob; Colson, Natalie Jane; Ovcaric, Micky; MacMillan, John; Griffiths, Lyn
Journal Name BMC Medical Genetics
Editor Jigisha Patel, MRCP PhD
Year Published 2007
Place of publication USA
Publisher Biomed Central
Abstract Background Migraine with aura (MA) is a subtype of typical migraine. Migraine with aura (MA) also encompasses a rare severe subtype Familial Hemiplegic Migraine (FHM) with several known genetic loci. The type 2 FHM (FHM-2) susceptibility locus maps to chromosome 1q23 and mutations in the ATP1A2 gene at this site have recently been implicated. We have previously provided evidence of linkage of typical migraine (predominantly MA) to microsatellite markers on chromosome 1, in the 1q31 and 1q23 regions. In this study, we have undertaken a large genomic investigation involving candidate genes that lie within the chromosome 1q23 and 1q31 regions using an association analysis approach. Methods We have genotyped a large population of case-controls (243 unrelated Caucasian migraineurs versus 243 controls) examining a set of 5 single nucleotide polymorphisms (SNPs) and the Fas Ligand dinucleotide repeat marker, located within the chromosome 1q23 and 1q31 regions. Results Several genes have been studied including membrane protein (ATP 1 subtype A4 and FasL), cytoplasmic glycoprotein (CASQ 1) genes and potassium (KCN J9 and KCN J10) and calcium (CACNA1E) channel genes in 243 migraineurs (including 85% MA and 15% of migraine without aura (MO)) and 243 matched controls. After correction for multiple testing, chi-square results showed non-significant P values (P > 0.008) across all SNPs (and a CA repeat) tested in these different genes, however results with the KCN J10 marker gave interesting results (P = 0.02) that may be worth exploring further in other populations. Conclusion These results do not show a significant role for the tested candidate gene variants and also do not support the hypothesis that a common chromosome 1 defective gene influences both FHM and the more common forms of migraine.
Peer Reviewed Yes
Published Yes
Publisher URI http://www.biomedcentral.com/1471-2350/8/57/abstract/
Alternative URI http://dx.doi.org/10.1186/1471-2350-8-57
Copyright Statement Copyright 2007 Fernandez et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Volume 8
Page from 1
Page to 8
ISSN 1471-2350
Date Accessioned 2008-01-15
Language en_AU
Comments Page numbers are not for citation purposes. Instead, this article has the unique article number of 57.
Research Centre Griffith Health Institute
Faculty Griffith Health Faculty
Subject Neurogenetics; Neurosciences
URI http://hdl.handle.net/10072/17786
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1

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