Alkaloids with Human δ-Opioid Receptor Binding Affinity from the Australian Rainforest Tree Peripentadenia mearsii
Author(s)
Katavic, Peter L
Venables, Debra A
Guymer, Gordon P
Forster, Paul I
Carroll, Anthony R
Griffith University Author(s)
Year published
2007
Metadata
Show full item recordAbstract
Three new pyrrolidine alkaloids, peripentonine A - C (2-4), one known pyrrolidine alkaloid peripentadenine (1) and one novel indolizidine alkaloid mearsamine (5) were isolated from the leaves of Peripentadenia mearsii and their structures determined by 1D and 2D NMR spectroscopy. Peripentonine A (2) and B (3) were isolated as a 1:1 mixture of inseparable diastereomers. Mearsamine (5) contains a novel tricyclic ring system. Peripentadenine, peripentonine A/B and C showed receptor binding affinity for the human d-opioid receptor with IC50 values of 11.4, 69.2 , and 30.9 卬 respectively. Mearsamine did not bind to the d-opioid receptor.Three new pyrrolidine alkaloids, peripentonine A - C (2-4), one known pyrrolidine alkaloid peripentadenine (1) and one novel indolizidine alkaloid mearsamine (5) were isolated from the leaves of Peripentadenia mearsii and their structures determined by 1D and 2D NMR spectroscopy. Peripentonine A (2) and B (3) were isolated as a 1:1 mixture of inseparable diastereomers. Mearsamine (5) contains a novel tricyclic ring system. Peripentadenine, peripentonine A/B and C showed receptor binding affinity for the human d-opioid receptor with IC50 values of 11.4, 69.2 , and 30.9 卬 respectively. Mearsamine did not bind to the d-opioid receptor.
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Journal Title
Journal of Natural Products
Volume
70
Issue
12
Publisher URI
Copyright Statement
© 2007 American Chemical Society. Self-archiving of the author-manuscript version is not yet supported by this publisher. The contents of this journal can be freely accessed online via the ACS web page 12 months after publication. Use hypertext link above to access the ACS website.
Subject
Chemical sciences
Biological sciences
Biomedical and clinical sciences