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dc.contributor.authorColson, NJ
dc.contributor.authorFernandez, F
dc.contributor.authorLea, RA
dc.contributor.authorGriffiths, LR
dc.date.accessioned2017-05-03T16:41:20Z
dc.date.available2017-05-03T16:41:20Z
dc.date.issued2007
dc.date.modified2010-08-26T07:36:54Z
dc.identifier.issn1420-682X
dc.identifier.doi10.1007/s00018-006-5592-y
dc.identifier.urihttp://hdl.handle.net/10072/18019
dc.description.abstractMigraine is a complex familial condition that imparts a significant burden on society. There is evidence for a role of genetic factors in migraine, and elucidating the genetic basis of this disabling condition remains the focus of much research. In this review we discuss results of genetic studies to date, from the discovery of the role of neural ion channel gene mutations in familial hemiplegic migraine (FHM) to linkage analyses and candidate gene studies in the more common forms of migraine. The success of FHM regarding discovery of genetic defects associated with the disorder remains elusive in common migraine, and causative genes have not yet been identified. Thus we suggest additional approaches for analysing the genetic basis of this disorder. The continuing search for migraine genes may aid in a greater understanding of the mechanisms that underlie the disorder and potentially lead to significant diagnostic and therapeutic applications.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherBirkhäuser Basel
dc.publisher.placeSwitzerland
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom331
dc.relation.ispartofpageto344
dc.relation.ispartofissue3
dc.relation.ispartofjournalCellular and Molecular Life Sciences (CMLS)
dc.relation.ispartofvolume64
dc.rights.retentionY
dc.subject.fieldofresearchBiochemistry and cell biology
dc.subject.fieldofresearchZoology
dc.subject.fieldofresearchClinical sciences
dc.subject.fieldofresearchcode3101
dc.subject.fieldofresearchcode3109
dc.subject.fieldofresearchcode3202
dc.titleThe search for migraine genes: an overview of current knowledge
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.facultyGriffith Health, School of Medical Science
gro.date.issued2007
gro.hasfulltextNo Full Text
gro.griffith.authorColson, Natalie J.


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    Contains articles published by Griffith authors in scholarly journals.

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