Biclusters visualization and detection using parallel coordinate plots

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Title Biclusters visualization and detection using parallel coordinate plots
Author Cheng, K.O.; Law, N.F.; Siu, W.C.; Liew, Alan Wee-Chung
Publication Title Proceedings of the International Symposium on Computational Models for Life Sciences
Editor Tuan Pham & Xiaobo Zhou
Year Published 2007
Place of publication USA
Publisher American Institute of Physics
Abstract The parallel coordinate (PC) plot is a powerful visualization tools for high-dimensional data. In this paper, we explore its usage on gene expression data analysis. We found that both the additive-related and the multiplicative-related coherent genes exhibit special patterns in the PC plots. One-dimensional clustering can then be applied to detect these patterns. Besides, a split-and-merge mechanism is employed to find the biggest coherent subsets inside the gene expression matrix. Experimental results showed that our proposed algorithm is effective in detecting various types of biclusters. In addition, the biclustering results can be visualized under a 2D setting, in which objective and subjective cluster quality evaluation can be performed.
Peer Reviewed Yes
Published Yes
Publisher URI http://scitation.aip.org/dbt/dbt.jsp?KEY=APCPCS&Volume=952&Issue=1
Alternative URI http://dx.doi.org/10.1063/1.2816614
Copyright Statement Copyright 2007 American Institute of Physics. The attached file is reproduced here in accordance with the copyright policy of the publisher. Use hypertext link for access to the conference website.
ISBN 9780735404663
Conference name International Symposium on Computational Models for Life Sciences
Location Gold Coast, Australia
Date From 2007-12-17
Date To 2007-12-19
URI http://hdl.handle.net/10072/18029
Date Accessioned 2008-03-06
Language en_AU
Research Centre Institute for Integrated and Intelligent Systems
Faculty Faculty of Science, Environment, Engineering and Technology
Subject PRE2009-Gene Expression; PRE2009-Pattern Recognition
Publication Type Conference Publications (Full Written Paper - Refereed)
Publication Type Code e1

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