Synthesis and evaluation of galactofuranosyl N,N-dialkyl sulfenamides and sulfonamides as antimycobacterial agents

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Title Synthesis and evaluation of galactofuranosyl N,N-dialkyl sulfenamides and sulfonamides as antimycobacterial agents
Author Owen, David James; Davis, Christopher; Hartnell, Regan David; Madge, Paul David; Thomson, Robin Joy; Chong, Andrew; Coppel, Ross L.; von Itzstein, Mark
Journal Name Bioorganic & Medicinal Chemistry Letters
Editor D.L. Boger, L. Ghosez and M. Shibasaki
Year Published 2007
Place of publication Oxford, UK
Publisher Pergamon Press
Abstract The recent emergence of clinically oppressive superbugs, some with resistance to nearly all frontline drug therapies, has challenged our ability to combat such infectious organisms as Mycobacterium tuberculosis, the causative agent of tuberculosis (TB). Our medicinal chemistry program targeting this pathogen has identified several potent galactofuranose-based in vitro inhibitors of mycobacterial growth. The most potent compound, the Galf N,N-didecyl sulfenamide 8d, displayed anti-mycobacterial activity (MIC) of 1 μg/mL in a cell based assay against a representative strain of Mycobacterium smegmatis.
Peer Reviewed Yes
Published Yes
Publisher URI http://www.elsevier.com/wps/find/journaldescription.cws_home/972/description#description
Alternative URI http://dx.doi.org/10.1016/j.bmcl.2007.01.068
Volume 17
Issue Number 8
Page from 2274
Page to 2277
ISSN 0960-894X
Date Accessioned 2008-02-26
Date Available 2009-09-21T05:50:20Z
Language en_AU
Research Centre Institute for Glycomics
Faculty Faculty of Science, Environment, Engineering and Technology
Subject PRE2009-Organic Chemical Synthesis
URI http://hdl.handle.net/10072/18268
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1

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