The war against influenza: discovery and development of sialidase inhibitors

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Title The war against influenza: discovery and development of sialidase inhibitors
Author von Itzstein, Mark
Journal Name Nature Reviews Drug Discovery
Year Published 2007
Place of publication UK
Publisher Nature Publishing Group
Abstract The threat of a major human influenza pandemic, in particular from highly aggressive strains such as avian H5N1, has emphasized the need for therapeutic strategies to combat these pathogens. At present, two inhibitors of sialidase (also known as neuraminidase), a viral enzyme that has a key role in the life cycle of influenza viruses, would be the mainstay of pharmacological strategies in the event of such a pandemic. This article provides a historical perspective on the discovery and development of these drugs — zanamivir and oseltamivir — and highlights the value of structure-based drug design in this process.
Peer Reviewed Yes
Published Yes
Publisher URI http://www.nature.com/nrd/index.html
Alternative URI http://dx.doi.org/10.1038/nrd2400
Volume 6
Page from 967
Page to 974
ISSN 1474-1776
Date Accessioned 2008-02-26
Date Available 2009-10-19T05:24:14Z
Language en_AU
Research Centre Institute for Glycomics
Faculty Faculty of Science, Environment, Engineering and Technology
Subject PRE2009-Organic Chemical Synthesis; PRE2009-Theoretical and Computational Chemistry
URI http://hdl.handle.net/10072/18269
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1

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