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dc.contributor.authorTindal, David J
dc.contributor.authorDyason, Jeffrey C
dc.contributor.authorThomson, Robin J
dc.contributor.authorSuzuki, Takashi
dc.contributor.authorUeyama, Hiroo
dc.contributor.authorKuwahara, Yohta
dc.contributor.authorMaki, Naoyoshi
dc.contributor.authorSuzuki, Yasuo
dc.contributor.authorvon Itzstein, Mark
dc.contributor.editorBoger, D. L.
dc.contributor.editorGhosez, L.
dc.contributor.editorShibasaki, M.
dc.date.accessioned2017-10-30T12:30:23Z
dc.date.available2017-10-30T12:30:23Z
dc.date.issued2007
dc.date.modified2009-10-19T05:24:18Z
dc.identifier.issn0960-894X
dc.identifier.doi10.1016/j.bmcl.2006.12.105
dc.identifier.urihttp://hdl.handle.net/10072/18270
dc.description.abstractThe X-ray crystal structure of the paramyxoviral surface glycoprotein haemagglutinin-neuraminidase (HN) from Newcastle Disease virus was used as a template to design inhibitors of the HN from human parainfluenza virus type-3 (hPIV-3). 4-O-Alkylated derivatives of 2-deoxy-2,3-didehydro-N-acetylneuraminic acid (Neu5Ac2en), accessed from 8,9-O-isopropylidenated-Neu5Ac2en1Me, were found to inhibit the sialidase (neuraminidase) activity of hPIV-3 (strain C243) in the range of 3-30 卮 This is comparable or improved activity compared to the parent 4-hydroxy compound.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherPergamon Press
dc.publisher.placeOxford, UK
dc.publisher.urihttp://www.elsevier.com/wps/find/journaldescription.cws_home/972/description#description
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom1655
dc.relation.ispartofpageto1658
dc.relation.ispartofjournalBioorganic & Medicinal Chemistry Letters
dc.relation.ispartofvolume17
dc.rights.retentionY
dc.subject.fieldofresearchMedicinal and biomolecular chemistry
dc.subject.fieldofresearchOrganic chemistry
dc.subject.fieldofresearchPharmacology and pharmaceutical sciences
dc.subject.fieldofresearchcode3404
dc.subject.fieldofresearchcode3405
dc.subject.fieldofresearchcode3214
dc.titleSynthesis and evaluation of 4-O-alkylated 2-deoxy-2,3-didehydro-N-acetylneuraminic acid derivatives as inhibitors of human parainfluenza virus type-3 sialidase activity
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2007
gro.hasfulltextNo Full Text
gro.griffith.authorvon Itzstein, Mark
gro.griffith.authorThomson, Robin J.


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