dc.contributor.author | Tindal, David J | |
dc.contributor.author | Dyason, Jeffrey C | |
dc.contributor.author | Thomson, Robin J | |
dc.contributor.author | Suzuki, Takashi | |
dc.contributor.author | Ueyama, Hiroo | |
dc.contributor.author | Kuwahara, Yohta | |
dc.contributor.author | Maki, Naoyoshi | |
dc.contributor.author | Suzuki, Yasuo | |
dc.contributor.author | von Itzstein, Mark | |
dc.contributor.editor | Boger, D. L. | |
dc.contributor.editor | Ghosez, L. | |
dc.contributor.editor | Shibasaki, M. | |
dc.date.accessioned | 2017-10-30T12:30:23Z | |
dc.date.available | 2017-10-30T12:30:23Z | |
dc.date.issued | 2007 | |
dc.date.modified | 2009-10-19T05:24:18Z | |
dc.identifier.issn | 0960-894X | |
dc.identifier.doi | 10.1016/j.bmcl.2006.12.105 | |
dc.identifier.uri | http://hdl.handle.net/10072/18270 | |
dc.description.abstract | The X-ray crystal structure of the paramyxoviral surface glycoprotein haemagglutinin-neuraminidase (HN) from Newcastle Disease virus was used as a template to design inhibitors of the HN from human parainfluenza virus type-3 (hPIV-3). 4-O-Alkylated derivatives of 2-deoxy-2,3-didehydro-N-acetylneuraminic acid (Neu5Ac2en), accessed from 8,9-O-isopropylidenated-Neu5Ac2en1Me, were found to inhibit the sialidase (neuraminidase) activity of hPIV-3 (strain C243) in the range of 3-30 卮 This is comparable or improved activity compared to the parent 4-hydroxy compound. | |
dc.description.peerreviewed | Yes | |
dc.description.publicationstatus | Yes | |
dc.language | English | |
dc.language.iso | eng | |
dc.publisher | Pergamon Press | |
dc.publisher.place | Oxford, UK | |
dc.publisher.uri | http://www.elsevier.com/wps/find/journaldescription.cws_home/972/description#description | |
dc.relation.ispartofstudentpublication | N | |
dc.relation.ispartofpagefrom | 1655 | |
dc.relation.ispartofpageto | 1658 | |
dc.relation.ispartofjournal | Bioorganic & Medicinal Chemistry Letters | |
dc.relation.ispartofvolume | 17 | |
dc.rights.retention | Y | |
dc.subject.fieldofresearch | Medicinal and biomolecular chemistry | |
dc.subject.fieldofresearch | Organic chemistry | |
dc.subject.fieldofresearch | Pharmacology and pharmaceutical sciences | |
dc.subject.fieldofresearchcode | 3404 | |
dc.subject.fieldofresearchcode | 3405 | |
dc.subject.fieldofresearchcode | 3214 | |
dc.title | Synthesis and evaluation of 4-O-alkylated 2-deoxy-2,3-didehydro-N-acetylneuraminic acid derivatives as inhibitors of human parainfluenza virus type-3 sialidase activity | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dc.type.code | C - Journal Articles | |
gro.date.issued | 2007 | |
gro.hasfulltext | No Full Text | |
gro.griffith.author | von Itzstein, Mark | |
gro.griffith.author | Thomson, Robin J. | |