Synthesis and evaluation of 4-O-alkylated 2-deoxy-2,3-didehydro-N-acetylneuraminic acid derivatives as inhibitors of human parainfluenza virus type-3 sialidase activity

There are no files associated with this record.

Title Synthesis and evaluation of 4-O-alkylated 2-deoxy-2,3-didehydro-N-acetylneuraminic acid derivatives as inhibitors of human parainfluenza virus type-3 sialidase activity
Author Tindal, David James; Dyason, Jeffrey Clifford; Thomson, Robin Joy; Suzuki, Takashi; Ueyama, Hiroo; Kuwahara, Yohta; Maki, Naoyoshi; Suzuki, Yasuo; von Itzstein, Mark
Journal Name Bioorganic & Medicinal Chemistry Letters
Editor D.L. Boger, L. Ghosez and M. Shibasaki
Year Published 2007
Place of publication Oxford, UK
Publisher Pergamon Press
Abstract The X-ray crystal structure of the paramyxoviral surface glycoprotein haemagglutinin-neuraminidase (HN) from Newcastle Disease virus was used as a template to design inhibitors of the HN from human parainfluenza virus type-3 (hPIV-3). 4-O-Alkylated derivatives of 2-deoxy-2,3-didehydro-N-acetylneuraminic acid (Neu5Ac2en), accessed from 8,9-O-isopropylidenated-Neu5Ac2en1Me, were found to inhibit the sialidase (neuraminidase) activity of hPIV-3 (strain C243) in the range of 3–30 μM. This is comparable or improved activity compared to the parent 4-hydroxy compound.
Peer Reviewed Yes
Published Yes
Publisher URI http://www.elsevier.com/wps/find/journaldescription.cws_home/972/description#description
Alternative URI http://dx.doi.org/10.1016/j.bmcl.2006.12.105
Volume 17
Page from 1655
Page to 1658
ISSN 0960-894X
Date Accessioned 2008-02-25
Date Available 2009-10-19T05:24:18Z
Language en_AU
Research Centre Institute for Glycomics
Faculty Faculty of Science, Environment, Engineering and Technology
Subject PRE2009-Organic Chemical Synthesis; PRE2009-Theoretical and Computational Chemistry
URI http://hdl.handle.net/10072/18270
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1

Show simple item record

Griffith University copyright notice