dc.contributor.author | Wang, Xiu-Fang | |
dc.contributor.author | Birringer, Marc | |
dc.contributor.author | Dong, Lan-Feng | |
dc.contributor.author | Veprek, Pavel | |
dc.contributor.author | Low, Pauline | |
dc.contributor.author | Swettenham, Emma | |
dc.contributor.author | Stantic, Marina | |
dc.contributor.author | Yuan, Lin-Hong | |
dc.contributor.author | Zobalova, Renata | |
dc.contributor.author | Vu, Kun | |
dc.contributor.author | Ledvina, Miroslav | |
dc.contributor.author | Ralph, Stephen J | |
dc.contributor.author | Neuzil, Jiri | |
dc.date.accessioned | 2017-05-03T12:22:10Z | |
dc.date.available | 2017-05-03T12:22:10Z | |
dc.date.issued | 2007 | |
dc.date.modified | 2009-09-09T07:17:31Z | |
dc.identifier.issn | 0008-5472 | |
dc.identifier.doi | 10.1158/0008-5472.CAN-06-2480 | |
dc.identifier.uri | http://hdl.handle.net/10072/18477 | |
dc.description.abstract | Overexpression of erbB2 is associated with resistance to apoptosis. We explored whether high level of erbB2 expression by cancer cells allows their targeting using an erbB2-binding peptide (LTVSPWY) attached to the proapoptotic A-tocopheryl succinate (A-TOS). Treating erbB2-low or erbB2-high cells with A-TOSinduced similar levels of apoptosis, whereas A-TOS-LTVSPWY induced greater levels of apoptosis in erbB2- high cells. A-TOSrapidly accumulated in erbB2-high cells exposed to A-TOS-LTVSPWY. The extent of apoptosis induced in erbB2-high cells by A-TOS-LTVSPWY was suppressed by erbB2 RNA interference as well as by inhibition of either endocytotic or lysosomal function. A-TOS-LTVSPWY reduced erbB2-high breast carcinomas in FVB/N c-neu transgenic mice. We conclude that a conjugate of a peptide targeting A-TOSto erbB2-overexpressing cancer cells induces rapid apoptosis and efficiently suppresses erbB2-positive breast tumors. | |
dc.description.peerreviewed | Yes | |
dc.description.publicationstatus | Yes | |
dc.language | English | |
dc.language.iso | eng | |
dc.publisher | American Association for Cancer Research | |
dc.publisher.place | United States | |
dc.publisher.uri | http://cancerres.aacrjournals.org/ | |
dc.relation.ispartofstudentpublication | N | |
dc.relation.ispartofpagefrom | 3337 | |
dc.relation.ispartofpageto | 3344 | |
dc.relation.ispartofissue | 7 | |
dc.relation.ispartofjournal | Cancer Research | |
dc.relation.ispartofvolume | 67 | |
dc.rights.retention | Y | |
dc.subject.fieldofresearch | Oncology and carcinogenesis | |
dc.subject.fieldofresearch | Biochemistry and cell biology | |
dc.subject.fieldofresearchcode | 3211 | |
dc.subject.fieldofresearchcode | 3101 | |
dc.title | A peptide conjugate of Vitamin E succinate targets breast cancer cells with high erbB2 expression | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dc.type.code | C - Journal Articles | |
gro.faculty | Griffith Health, School of Medicine | |
gro.rights.copyright | © 2007 AACR. Please refer to the journal link for access to the definitive, published version. | |
gro.date.issued | 2007 | |
gro.hasfulltext | No Full Text | |
gro.griffith.author | Neuzil, Jiri | |
gro.griffith.author | Ralph, Stephen J. | |