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dc.contributor.authorWang, Xiu-Fang
dc.contributor.authorBirringer, Marc
dc.contributor.authorDong, Lan-Feng
dc.contributor.authorVeprek, Pavel
dc.contributor.authorLow, Pauline
dc.contributor.authorSwettenham, Emma
dc.contributor.authorStantic, Marina
dc.contributor.authorYuan, Lin-Hong
dc.contributor.authorZobalova, Renata
dc.contributor.authorVu, Kun
dc.contributor.authorLedvina, Miroslav
dc.contributor.authorRalph, Stephen J
dc.contributor.authorNeuzil, Jiri
dc.date.accessioned2017-05-03T12:22:10Z
dc.date.available2017-05-03T12:22:10Z
dc.date.issued2007
dc.date.modified2009-09-09T07:17:31Z
dc.identifier.issn0008-5472
dc.identifier.doi10.1158/0008-5472.CAN-06-2480
dc.identifier.urihttp://hdl.handle.net/10072/18477
dc.description.abstractOverexpression of erbB2 is associated with resistance to apoptosis. We explored whether high level of erbB2 expression by cancer cells allows their targeting using an erbB2-binding peptide (LTVSPWY) attached to the proapoptotic A-tocopheryl succinate (A-TOS). Treating erbB2-low or erbB2-high cells with A-TOSinduced similar levels of apoptosis, whereas A-TOS-LTVSPWY induced greater levels of apoptosis in erbB2- high cells. A-TOSrapidly accumulated in erbB2-high cells exposed to A-TOS-LTVSPWY. The extent of apoptosis induced in erbB2-high cells by A-TOS-LTVSPWY was suppressed by erbB2 RNA interference as well as by inhibition of either endocytotic or lysosomal function. A-TOS-LTVSPWY reduced erbB2-high breast carcinomas in FVB/N c-neu transgenic mice. We conclude that a conjugate of a peptide targeting A-TOSto erbB2-overexpressing cancer cells induces rapid apoptosis and efficiently suppresses erbB2-positive breast tumors.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherAmerican Association for Cancer Research
dc.publisher.placeUnited States
dc.publisher.urihttp://cancerres.aacrjournals.org/
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom3337
dc.relation.ispartofpageto3344
dc.relation.ispartofissue7
dc.relation.ispartofjournalCancer Research
dc.relation.ispartofvolume67
dc.rights.retentionY
dc.subject.fieldofresearchOncology and carcinogenesis
dc.subject.fieldofresearchBiochemistry and cell biology
dc.subject.fieldofresearchcode3211
dc.subject.fieldofresearchcode3101
dc.titleA peptide conjugate of Vitamin E succinate targets breast cancer cells with high erbB2 expression
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.facultyGriffith Health, School of Medicine
gro.rights.copyright© 2007 AACR. Please refer to the journal link for access to the definitive, published version.
gro.date.issued2007
gro.hasfulltextNo Full Text
gro.griffith.authorNeuzil, Jiri
gro.griffith.authorRalph, Stephen J.


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