Mitocans as anti-cancer agents targeting mitochondria: lessons from studies with vitamin E analogues, inhibitors of complex II

There are no files associated with this record.

Title Mitocans as anti-cancer agents targeting mitochondria: lessons from studies with vitamin E analogues, inhibitors of complex II
Author Neuzil, Jiri; Dyason, Jeffrey Clifford; Freeman, Ruth; Dong, Lan-feng; Prochazka, Lubomir; Wang, Xiufang; Scheffler, Immo; Ralph, Stephen John
Journal Name Journal of Bioenergetics and Biomembranes
Editor P.L. Pedersen
Year Published 2007
Place of publication New York, USA
Publisher Springer
Abstract Recently mitochondria in cancer cells have emerged as the Achilles heel for tumour destruction. Anti-cancer agents specifically targeting cancer cell mitochondria are referred to as 'mitocans'. These compounds act by destabilising these organelles, unleashing their apoptogenic potential, resulting in the efficient death of malignant cells and suppression of tumour growth. Importantly, at least some mitocans are selective for cancer cells, and these are represented by the group of redox-silent vitamin E analogues, epitomised by α-tocopheryl succinate (α-TOS). This compound has proven itself in pre-clinical models to be an efficient anti-cancer agent, targeting complex II of the respiratory chain to displace ubiquinone binding. We propose that disrupting the electron flow of mitochondrial complex II results in generation of superoxide, triggering mitochondrial destabilisation and initiation of apoptotic pathways. Moreover, α-TOS is selective for cancer cells with their reduced anti-oxidant defenses and lower esterase activity than the normal (non-malignant) counterparts. In this mini-review we discuss the emerging significance of mitocans, as exemplified by α-TOS.
Peer Reviewed Yes
Published Yes
Alternative URI http://dx.doi.org/10.1007/s10863-006-9060-z
Volume 39
Issue Number 1
Page from 65
Page to 72
ISSN 0145-479X
Date Accessioned 2008-02-28
Language en_AU
Research Centre Griffith Health Institute; Molecular Basis of Disease
Faculty Griffith Health Faculty
Subject PRE2009-Cell Development (incl. Cell Division and Apoptosis)
URI http://hdl.handle.net/10072/18479
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1

Show simple item record

Griffith University copyright notice