Oral lichen planus and oral lichenoid lesions: diagnostic and therapeutic considerations

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Title Oral lichen planus and oral lichenoid lesions: diagnostic and therapeutic considerations
Author Al-Hashimi, Ibtisam; Schifter, Mark; Lockhart, Peter B.; Wray, David; Brennan, Michael; Migliorati, Cesar A.; Axell, Tony; Bruce, Alison J.; Carpenter, William; Eisenberg, Ellen; Epstein, Joel B.; Holmstrup, Palle; Jontell, Mats; Lozada-Nur, Francina; Nair, Raj; Silverman, Bud; Thongprasom, Kobkan; Thornhill, Martin; Warnakulasuriya, Saman; Waal, Isaac van der
Journal Name Oral surgery, oral medicine, oral pathology, oral radiology and endodontology
Year Published 2007
Place of publication United States
Publisher Mosby, Inc.
Abstract Several therapeutic agents have been investigated for the treatment of oral lichen planus (OLP). Among these are corticosteroids, retinoids, cyclosporine, and phototherapy, in addition to other treatment modalities. A systematic review of clinical trials showed that particularly topical corticosteroids are often effective in the management of symptomatic OLP lichen planus. Systemic corticosteroids should be only considered for severe widespread OLP and for lichen planus involving other mucocutaneous sites. Because of the ongoing controversy in the literature about the possible premalignant character of OLP, periodic follow-up is recommended. There is a spectrum of oral lichen planus-like ("lichenoid") lesions that may confuse the differential diagnosis. These include lichenoid contact lesions, lichenoid drug reactions and lichenoid lesions of graft-versus-host disease. In regard to the approach to oral lichenoid contact lesions the value of patch testing remains controversial. Confirmation of the diagnosis of an oral lichenoid drug reaction may be difficult, since empiric withdrawal of the suspected drug and/or its substitution by an alternative agent may be complicated. Oral lichenoid lesions of graft-versus-host disease (OLL-GVHD) are recognized to have an association with malignancy. Local therapy for these lesions rests in topical agents, predominantly corticosteroids.
Peer Reviewed Yes
Published Yes
Volume 103
Issue Number 3
Edition Suppliment 1
Page from S25.E1
Page to S25.E12
ISSN 1079-2104
Date Accessioned 2007-07-12
Language en_AU
Faculty Griffith Health Faculty
Subject Dentistry
URI http://hdl.handle.net/10072/19093
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1

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