Spectral analysis of microarray gene expression time series data of Plasmodium falciparum

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Title Spectral analysis of microarray gene expression time series data of Plasmodium falciparum
Author Du, Liping; Wu, Shuanhu; Liew, Alan Wee-Chung; Smith, David K.; Yan, Hong
Journal Name International Journal of Bioinformatics Research and Applications
Year Published 2008
Place of publication United States
Publisher Inderscience
Abstract We propose a new strategy to analyze the periodicity of gene expression profiles using Singular Spectrum Analysis (SSA) and Autoregressive (AR) model based spectral estimation. By combining the advantages of SSA and AR modeling, more periodic genes are extracted in the Plasmodium falciparum data set, compared with the classical Fourier analysis technique. We are able to identify more gene targets for new drug discovery, and by checking against the seven well-known malaria vaccine candidates, we have found five additional genes that warrant further biological verification.
Peer Reviewed Yes
Published Yes
Alternative URI http://dx.doi.org/10.1504/IJBRA.2008.019579
Copyright Statement Copyright 2008 Inderscience Publishers. This is the author-manuscript version of this paper. Reproduced in accordance with the copyright policy of the publisher. Please refer to the journal website for access to the definitive, published version.
Volume 4
Issue Number 3
Page from 337
Page to 349
ISSN 1744-5485
Date Accessioned 2008-06-16
Language en_AU
Research Centre Institute for Integrated and Intelligent Systems
Faculty Faculty of Science, Environment, Engineering and Technology
Subject PRE2009-Gene Expression; PRE2009-Signal Processing
URI http://hdl.handle.net/10072/20270
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1

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