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dc.contributor.authorFrith, Martin C.
dc.contributor.authorForrest, Alistair R.
dc.contributor.authorNourbakhsh, Ehsan
dc.contributor.authorPang, Ken C.
dc.contributor.authorKai, Chikatoshi
dc.contributor.authorKawai, Jun
dc.contributor.authorCarninci, Piero
dc.contributor.authorHayashizaki, Yoshihide
dc.contributor.authorBailey, Timothy L.
dc.contributor.authorGrimmond, Sean M.
dc.date.accessioned2017-05-03T15:01:21Z
dc.date.available2017-05-03T15:01:21Z
dc.date.issued2006
dc.date.modified2008-11-25T05:37:39Z
dc.identifier.issn1553-7390
dc.identifier.doi10.1371/journal.pgen.0020052
dc.identifier.urihttp://hdl.handle.net/10072/20565
dc.description.abstractShort proteins play key roles in cell signalling and other processes, but their abundance in the mammalian proteome is unknown. Current catalogues of mammalian proteins exhibit an artefactual discontinuity at a length of 100 aa, so that protein abundance peaks just above this length and falls off sharply below it. To clarify the abundance of short proteins, we identify proteins in the FANTOM collection of mouse cDNAs by analysing synonymous and non-synonymous substitutions with the computer program CRITICA. This analysis confirms that there is no real discontinuity at length 100. Roughly 10% of mouse proteins are shorter than 100 aa, although the majority of these are variants of proteins longer than 100 aa. We identify many novel short proteins, including a "dark matter" subset containing ones that lack detectable homology to other known proteins. Translation assays confirm that some of these novel proteins can be translated and localised to the secretory pathway
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.format.extent675017 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglish
dc.language.isoeng
dc.publisherPublic Library of Science
dc.publisher.placeUnited States
dc.publisher.urihttp://www.plosgenetics.org/home.action
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefromE52
dc.relation.ispartofpagetoE52
dc.relation.ispartofissue4
dc.relation.ispartofjournalPLoS Genetics
dc.relation.ispartofvolume2
dc.rights.retentionY
dc.subject.fieldofresearchGenetics
dc.subject.fieldofresearchcode0604
dc.titleThe Abundance of Short Proteins in the Mammalian Proteome
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dcterms.licensehttp://www.plos.org/journals/license.html
gro.rights.copyright© 2006 Frith et al. This is an Open Access article distributed under the terms of the Creative Commons Attribution License CCAL. (http://www.plos.org/journals/license.html)
gro.date.issued2006
gro.hasfulltextFull Text
gro.griffith.authorForrest, Alistair RR.


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