Colloidal metallic gold is not bio-inert

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Title Colloidal metallic gold is not bio-inert
Author Brown, Chris; Whitehouse, Michael; Tiekink, Edward Richard Tom; Bushell, Gillian Robin
Journal Name Inflammopharmacology
Year Published 2008
Place of publication Switzerland
Publisher Birkhauser Verlag
Abstract Metallic gold (Au°) is a likely biotransformation product of monovalent gold, Au(I) whenever it is dissociated from in vivo ligands, Au° being formed either by bioreduction or by spontaneous dismutation (with co-production of trivalent gold). This review discusses the preparation and some biologically relevant properties of colloidal metallic gold (CMG) in its nano-particulate form. Tyndall's purple, a well characterised preparation of CMG, shows potent anti-arthritic activity in rats, approximately 103 times that of sodium aurothiomalate (Myocrysin). Even more remarkable is its broader spectrum of action in rats compared to this classic DMARD.
Peer Reviewed Yes
Published Yes
Alternative URI http://dx.doi.org/10.1007/s10787-007-0017-6
Volume 16
Page from 133
Page to 137
ISSN 0925-4692
Date Accessioned 2008-06-06
Date Available 2011-06-13T22:57:56Z
Language en_AU
Research Centre Eskitis Institute for Drug Discovery; Griffith Medical Research College; Queensland Micro and Nanotechnology Centre
Faculty Faculty of Science, Environment, Engineering and Technology
Subject PRE2009-Bioinorganic Chemistry
URI http://hdl.handle.net/10072/21294
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1

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