The macrophage-inducible C-type lectin, mincle, is an essential component of the innate immune response to Candida albicans

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Title The macrophage-inducible C-type lectin, mincle, is an essential component of the innate immune response to Candida albicans
Author Wells, Christine; Salvage-Jones, Judith Anne; Li, Xin; Hitchens, Kelly Jane; Butcher, Suzanne; Murray, Rachel Z.; Beckhouse, Anthony Gordon; Lo, Yu-Lan Sandra; Manzanero Alonso, Silvia; Cobbold, Christian James; Schroder, Kate; Ma, Bo; Orr, Sally; Stewart, Lauren; Lebus, Daniel; Sobieszczuk, Peter; Hume, David A.; Stow, Jennifer; Blanchard, Helen; Ashman, Robert Brian
Journal Name Journal of Immunology
Editor Jeremy M. Boss
Year Published 2008
Place of publication Bethesda MD
Publisher American Association of Immunologists
Abstract The recognition of carbohydrate moieties by cells of the innate immune system is emerging as an essential element in antifungal immunity, but despite the number and diversity of lectins expressed by innate immune cells, few carbohydrate receptors have been characterized. Mincle, a C-type lectin, is expressed predominantly on macrophages, and is here shown to play a role in macrophage responses to the yeast Candida albicans. After exposure to the yeast in vitro, Mincle localized to the phagocytic cup, but it was not essential for phagocytosis. In the absence of Mincle, production of TNF-{alpha} by macrophages was reduced, both in vivo and in vitro. In addition, mice lacking Mincle showed a significantly increased susceptibility to systemic candidiasis. Thus, Mincle plays a novel and nonredundant role in the induction of inflammatory signaling in response to C. albicans infection.
Peer Reviewed Yes
Published Yes
Publisher URI http://www.jimmunol.org/content/180/11/7404.short
Copyright Statement Self-archiving of the author-manuscript version is not yet supported by this journal. Please refer to the journal link for access to the definitive, published version or contact the author[s] for more information.
Volume 180
Issue Number 11
Page from 7404
Page to 7413
ISSN 0022-1767
Date Accessioned 2008-07-08
Date Available 2011-07-09T02:30:47Z
Language en_AU
Research Centre Institute for Glycomics
Faculty Faculty of Science, Environment, Engineering and Technology
Subject PRE2009-Biochemistry and Cell Biology
URI http://hdl.handle.net/10072/21351
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1

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