Antimicrobial Activity of Aloe barbadensis Miller Leaf Gel Components

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Title Antimicrobial Activity of Aloe barbadensis Miller Leaf Gel Components
Author Cock, Ian Edwin
Journal Name The Internet Journal of Microbiology
Year Published 2008
Place of publication United States
Publisher Internet Scientific Publications LLC
Abstract Methanolic extracts of Aloe barbadensis Miller inner leaf gel were fractionated by RP-HPLC and the resultant fractions were tested for inhibitory activity against a panel of bacteria and fungi. Five fractions were identified as having antimicrobial activity. Fraction 1 had the broadest antibacterial activity, being capable of inhibiting growth of both Gram-positive and Gram-negative bacteria as well as inhibiting growth of a nystatin resistant strain of the fungus Aspergillus niger. Fraction 1 had similar UV spectral properties as aloe emodin and was chromatographically identical to the pure compound. The other fractions tested were much more selective in their antimicrobial activities, being only capable of inhibiting the growth of specific Gram-negative rod bacteria. Two of these antimicrobial fractions were identified by ESI mass spectroscopy as being isomers of 8-C-β-D-[2-0-(E)-coumaroyl] glucopyranosyl -2-[2-hydroxy]-propyl-7-methoxy-5-methylchromone.
Peer Reviewed Yes
Published Yes
Publisher URI
Copyright Statement Copyright 2008 Internet Scientific Publications.This is the author-manuscript version of this paper. Reproduced in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.
Volume 4
Issue Number 2
Page from 1
Page to 11
ISSN 1937-8289
Date Accessioned 2008-06-02
Date Available 2015-08-04T00:17:48Z
Language en_US
Research Centre Environmental Futures Research Institute
Faculty Faculty of Science, Environment, Engineering and Technology
Subject PRE2009-Bacteriology
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1

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