Human and mouse macrophage-inducible C-type lectin (Mincle) bind Candida albicans

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Title Human and mouse macrophage-inducible C-type lectin (Mincle) bind Candida albicans
Author Bugarcic, Andrea; Hitchens, Kelly Jane; Beckhouse, Anthony Gordon; Wells, Christine; Ashman, Robert B.; Blanchard, Helen
Journal Name Glycobiology
Editor Ronald Schnaar
Year Published 2008
Place of publication United States
Publisher Oxford University Press
Abstract Candida albicans is a causative agent in mycoses of the skin, oral cavity and gastrointestinal tract. Identification of receptors, and their respective ligands, that are engaged by immune cells when in contact with C. albicans is crucial for understanding inflammatory responses leading to invasive candidiasis. Mincle is a recently identified macrophage-expressed receptor that is important for host responses to C. albicans. The carbohydrate-recognition domain of human and mouse Mincle were expressed, purified under denaturing conditions and successfully refolded. In addition to oligomers, there are isolatable monomeric and dimeric forms of the protein that occur under two different buffer solutions. The human and mouse homologues bound yeast extract, and the isolated dimeric and monomeric species also demonstrated recognition of whole C. albicans yeast cells. The data is indicative of several functional states mediating the interaction of Mincle and yeast at the surface of the macrophage.
Peer Reviewed Yes
Published Yes
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Copyright Statement Copyright 2008 Oxford University Press. Please refer to the link for the definitive publisher-authenticated version.
Volume 18
Issue Number 9
Page from 679
Page to 685
ISSN 0959-6658
Date Accessioned 2008-10-07
Language en_AU
Research Centre Institute for Glycomics
Faculty Faculty of Science, Environment, Engineering and Technology
Subject PRE2009-Characterisation of Macromolecules
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1

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