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dc.contributor.authorOberg, Christopher T
dc.contributor.authorBlanchard, Helen
dc.contributor.authorLeffler, Hakon
dc.contributor.authorNilsson, Ulf J
dc.date.accessioned2017-05-03T14:15:04Z
dc.date.available2017-05-03T14:15:04Z
dc.date.issued2008
dc.date.modified2011-06-09T22:41:13Z
dc.identifier.issn0960-894X
dc.identifier.doi10.1016/j.bmcl.2008.05.066
dc.identifier.urihttp://hdl.handle.net/10072/21598
dc.description.abstractA series of O2 and O3-derivatized methyl ߭d-talopyranosides were synthesized and evaluated in vitro as inhibitors of the galactose-binding galectin-1, -2, -3, -4 (N- and C-terminal domains), 8 (N-terminal domain), and 9 (N-terminal domain). Galectin-4C and 8N were found to prefer the d-talopyranose configuration to the natural ligand d-galactopyranose configuration. Derivatization at talose O2 and/or O3 provided selective submillimolar inhibitors for these two galectins.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.publisher.placeUnited Kingdom
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom3691
dc.relation.ispartofpageto3694
dc.relation.ispartofissue13
dc.relation.ispartofjournalBioorganic and Medicinal Chemistry Letters
dc.relation.ispartofvolume18
dc.rights.retentionY
dc.subject.fieldofresearchMedicinal and biomolecular chemistry
dc.subject.fieldofresearchOrganic chemistry
dc.subject.fieldofresearchPharmacology and pharmaceutical sciences
dc.subject.fieldofresearchcode3404
dc.subject.fieldofresearchcode3405
dc.subject.fieldofresearchcode3214
dc.titleProtein subtype-targeting through ligand epimerization: Talose-selectivity of galectin-4 and galectin-8
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2008
gro.hasfulltextNo Full Text
gro.griffith.authorBlanchard, Helen


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