Parametric Spectral Analysis of Malaria Gene Expression Time Series Data

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Title Parametric Spectral Analysis of Malaria Gene Expression Time Series Data
Author Du, Liping; Wu, Shuanhu; Liew, Alan Wee-Chung; Smith, David Keith; Yan, Hong
Journal Name Lecture Notes in Computer Science
Year Published 2006
Place of publication Germany
Publisher Springer Berlin / Heidelberg
Abstract Spectral analysis of DNA microarray gene expressions time series data is important for understanding the regulation of gene expression and gene function of the Plasmodium falciparum in the intraerythrocytic developmental cycle. In this paper, we propose a new strategy to analyze the cell cycle regulation of gene expression profiles based on the combination of singular spectrum analysis (SSA) and autoregressive (AR) spectral estimation. Using the SSA, we extract the dominant trend of data and reduce the effect of noise. Based on the AR analysis, high resolution spectra can be produced. Experiment results show that our method can extract more genes and the information can be useful for new drug design.
Peer Reviewed Yes
Published Yes
Alternative URI
Volume 4216
Page from 32
Page to 41
ISSN 0302-9743
Date Accessioned 2007-04-27
Language en_AU
Research Centre Institute for Integrated and Intelligent Systems
Faculty Faculty of Engineering and Information Technology
Subject PRE2009-Gene Expression; PRE2009-Signal Processing
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1x

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