dc.contributor.author | Stensløkken, KO | |
dc.contributor.author | Milton, SL | |
dc.contributor.author | Lutz, PL | |
dc.contributor.author | Sundin, L | |
dc.contributor.author | Renshaw, GMC | |
dc.contributor.author | Stecyk, JAW | |
dc.contributor.author | Nilsson, GE | |
dc.contributor.editor | Patrick J. Walsh (Editor-in-Chief), Thomas P Mommsen (Editor-in-Chief) | |
dc.date.accessioned | 2017-10-23T04:18:10Z | |
dc.date.available | 2017-10-23T04:18:10Z | |
dc.date.issued | 2008 | |
dc.date.modified | 2009-04-09T22:37:46Z | |
dc.identifier.issn | 1095-6433 | |
dc.identifier.doi | 10.1016/j.cbpa.2008.03.022 | |
dc.identifier.uri | http://hdl.handle.net/10072/22112 | |
dc.description.abstract | To survive anoxia, neural ATP levels have to be defended. Reducing electrical activity, which accounts for 50% or more of neural energy consumption, should be beneficial for anoxic survival. The retina is a hypoxia sensitive part of the central nervous system. Here, we quantify the in vivo retinal light response (electroretinogram; ERG) in three vertebrates that exhibit varying degrees of anoxia tolerance: freshwater turtle (Trachemys scripta), epaulette shark (Hemiscyllium ocellatum) and leopard frog (Rana pipiens). A virtually total suppression of ERG in anoxia, probably resulting in functional blindness, has previously been seen in the extremely anoxia-tolerant crucian carp (Carassius carassius). Surprisingly, the equally anoxiatolerant turtle, which strongly depresses brain and whole-body metabolism during anoxia, exhibited a relatively modest anoxic reduction in ERG: the combined amplitude of turtle ERG waves was reduced by ~50% after 2 h. In contrast, the shark b-wave amplitude practically disappeared after 30 min of severe hypoxia, and the frog b-wave was decreased by ~75% after 40 min in anoxia. The specific A1 adenosine receptor antagonist CPT significantly delayed the suppression of turtle ERG, while the hypoxic shark ERG was unaffected by the non-specific adenosine receptor antagonist aminophylline, suggesting adenosinergic involvement in turtle but not in shark. | |
dc.description.peerreviewed | Yes | |
dc.description.publicationstatus | Yes | |
dc.language | English | |
dc.language.iso | eng | |
dc.publisher | Elsevier | |
dc.publisher.place | Amsterdam, The Netherlands, | |
dc.relation.ispartofstudentpublication | N | |
dc.relation.ispartofpagefrom | 395 | |
dc.relation.ispartofpageto | 403 | |
dc.relation.ispartofissue | 4 | |
dc.relation.ispartofjournal | Comparative Biochemistry and Physiology - A Molecular and Integrative Physiology | |
dc.relation.ispartofvolume | 150 | |
dc.rights.retention | Y | |
dc.subject.fieldofresearch | Biochemistry and cell biology | |
dc.subject.fieldofresearch | Biological adaptation | |
dc.subject.fieldofresearch | Zoology | |
dc.subject.fieldofresearchcode | 3101 | |
dc.subject.fieldofresearchcode | 310403 | |
dc.subject.fieldofresearchcode | 3109 | |
dc.title | Effect of anoxia on the electroretinogram of three anoxia-tolerant vertebrates | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dc.type.code | C - Journal Articles | |
gro.date.issued | 2008 | |
gro.hasfulltext | No Full Text | |
gro.griffith.author | Renshaw, Gillian M. | |