Effect of anoxia on the electroretinogram of three anoxia-tolerant vertebrates

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Title Effect of anoxia on the electroretinogram of three anoxia-tolerant vertebrates
Author Stenslokken, Kare-Olav; Milton, Sarah L.; Lutz, Peter L.; Sundin, lena; Renshaw, Gillian Mary Claire; Stecyk, Jonathan A. W.; Nilsson, Goran E.
Journal Name Comparative Biochemistry and Physiology - A Molecular and Integrative Physiology
Editor Patrick J. Walsh (Editor-in-Chief), Thomas P Mommsen (Editor-in-Chief)
Year Published 2008
Place of publication Amsterdam, The Netherlands,
Publisher Elsvier
Abstract To survive anoxia, neural ATP levels have to be defended. Reducing electrical activity, which accounts for 50% or more of neural energy consumption, should be beneficial for anoxic survival. The retina is a hypoxia sensitive part of the central nervous system. Here, we quantify the in vivo retinal light response (electroretinogram; ERG) in three vertebrates that exhibit varying degrees of anoxia tolerance: freshwater turtle (Trachemys scripta), epaulette shark (Hemiscyllium ocellatum) and leopard frog (Rana pipiens). A virtually total suppression of ERG in anoxia, probably resulting in functional blindness, has previously been seen in the extremely anoxia-tolerant crucian carp (Carassius carassius). Surprisingly, the equally anoxiatolerant turtle, which strongly depresses brain and whole-body metabolism during anoxia, exhibited a relatively modest anoxic reduction in ERG: the combined amplitude of turtle ERG waves was reduced by ~50% after 2 h. In contrast, the shark b-wave amplitude practically disappeared after 30 min of severe hypoxia, and the frog b-wave was decreased by ~75% after 40 min in anoxia. The specific A1 adenosine receptor antagonist CPT significantly delayed the suppression of turtle ERG, while the hypoxic shark ERG was unaffected by the non-specific adenosine receptor antagonist aminophylline, suggesting adenosinergic involvement in turtle but not in shark.
Peer Reviewed Yes
Published Yes
Publisher URI http://www.elsevier.com/locate/cbpa
Alternative URI http://dx.doi.org/10.1016/j.cbpa.2008.03.022
Copyright Statement Copyright 2008 Elsevier. Please refer to the journal's website for access to the definitive, published version.
Volume 152
Page from 395
Page to 403
ISSN 1095-6433
Date Accessioned 2009-03-13
Language en_AU
Research Centre Heart Foundation Research Centre; Menzies Health Institute Qld
Faculty Griffith Health Faculty
Subject Biological Adaptation
URI http://hdl.handle.net/10072/22112
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1

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