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dc.contributor.authorWest, NP
dc.contributor.authorPyne, DB
dc.contributor.authorKyd, JM
dc.contributor.authorRenshaw, GM
dc.contributor.authorFricker, PA
dc.contributor.authorCripps, AW
dc.date.accessioned2017-05-03T12:01:35Z
dc.date.available2017-05-03T12:01:35Z
dc.date.issued2010
dc.date.modified2011-09-07T06:12:08Z
dc.identifier.issn0306-3674
dc.identifier.doi10.1136/bjsm.2008.046532
dc.identifier.urihttp://hdl.handle.net/10072/22113
dc.description.abstractWe conducted a prospective observational study comparing salivary lactoferrin and lysozyme concentration over five months (chronic changes) in elite rowers (n=17, mean age 24.3 ᠴ.0y) with sedentary individuals (controls) (n=18, mean age = 27.2 ᠷ.1 y) and a graded exercise test to exhaustion (acute changes) with a cohort of elite rowers (n=11, mean age 24.7 ᠴ.1). Magnitudes of differences and changes were interpreted as a standardized (Cohen's) effect size (ES). Lactoferrin concentration in the observational study was approximately 60% lower in rowers than control subjects at baseline (7.9 ᠱ.2 姮ml-1 mean ᠓EM, 19.4 ᠵ.6 姮ml-1, P=0.05, ES=0.68, 'moderate') and at the midpoint of the season (6.4 ᠱ.4 姮ml-1 mean ᠓EM, 21.5 ᠴ.2 姮ml-1, P=0.001, ES=0.89, 'moderate'). The concentration of lactoferrin at the end of the study was not statistically significant (P=0.1) between the groups. There was no significant difference between rowers and control subjects in lysozyme concentration during the study. There was a 50% increase in the concentration of lactoferrin (P=0.05, ES=1.04, 'moderate') and 55% increase in lysozyme (P=0.01, ES=3.0, 'very large') from pre-exercise to exhaustion in the graded exercise session. Lower concentrations of these proteins may be indicative of an impairment of innate protection of the upper respiratory tract. Increased salivary lactoferrin and lysozyme concentration following exhaustive exercise may be due to a transient activation response that increases protection in the immediate post exercise period.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.format.extent194215 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglish
dc.language.isoeng
dc.publisherBMJ Publishing Group Ltd
dc.publisher.placeUnited Kingdom
dc.publisher.urihttp://bjsm.bmj.com/
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom227
dc.relation.ispartofpageto231
dc.relation.ispartofjournalBritish Journal of Sports Medicine
dc.relation.ispartofvolume44
dc.rights.retentionY
dc.subject.fieldofresearchEngineering
dc.subject.fieldofresearchBiomedical and clinical sciences
dc.subject.fieldofresearchInnate immunity
dc.subject.fieldofresearchEducation
dc.subject.fieldofresearchClinical sciences
dc.subject.fieldofresearchSports science and exercise
dc.subject.fieldofresearchApplied and developmental psychology
dc.subject.fieldofresearchcode40
dc.subject.fieldofresearchcode32
dc.subject.fieldofresearchcode320407
dc.subject.fieldofresearchcode39
dc.subject.fieldofresearchcode3202
dc.subject.fieldofresearchcode4207
dc.subject.fieldofresearchcode5201
dc.titleThe effect of exercise on innate mucosal immunity
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.facultyGriffith Health, School of Allied Health Sciences
gro.rights.copyright© The Author(s) 2008. The attached file is posted here with permission of the copyright owners for your personal use only. No further distribution permitted. For information about this journal please refer to the publisher's website or contact the authors.
gro.date.issued2010
gro.hasfulltextFull Text
gro.griffith.authorCripps, Allan W.
gro.griffith.authorWest, Nic P.


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