The effect of exercise on innate mucosal immunity

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Title The effect of exercise on innate mucosal immunity
Author West, Nic; Pyne, D.B.; Kyd, J. M.; Renshaw, Gillian Mary Claire; Fricker, P.A.; Cripps, Allan W
Journal Name British Journal of Sports Medicine
Year Published 2010
Place of publication United Kingdom
Publisher BMJ Publishing Group Ltd
Abstract We conducted a prospective observational study comparing salivary lactoferrin and lysozyme concentration over five months (chronic changes) in elite rowers (n=17, mean age 24.3 ± 4.0y) with sedentary individuals (controls) (n=18, mean age = 27.2 ± 7.1 y) and a graded exercise test to exhaustion (acute changes) with a cohort of elite rowers (n=11, mean age 24.7 ± 4.1). Magnitudes of differences and changes were interpreted as a standardized (Cohen's) effect size (ES). Lactoferrin concentration in the observational study was approximately 60% lower in rowers than control subjects at baseline (7.9 ± 1.2 μg.ml-1 mean ± SEM, 19.4 ± 5.6 μg.ml-1, P=0.05, ES=0.68, 'moderate') and at the midpoint of the season (6.4 ± 1.4 μg.ml-1 mean ± SEM, 21.5 ± 4.2 μg.ml-1, P=0.001, ES=0.89, 'moderate'). The concentration of lactoferrin at the end of the study was not statistically significant (P=0.1) between the groups. There was no significant difference between rowers and control subjects in lysozyme concentration during the study. There was a 50% increase in the concentration of lactoferrin (P=0.05, ES=1.04, 'moderate') and 55% increase in lysozyme (P=0.01, ES=3.0, 'very large') from pre-exercise to exhaustion in the graded exercise session. Lower concentrations of these proteins may be indicative of an impairment of innate protection of the upper respiratory tract. Increased salivary lactoferrin and lysozyme concentration following exhaustive exercise may be due to a transient activation response that increases protection in the immediate post exercise period.
Peer Reviewed Yes
Published Yes
Publisher URI http://bjsm.bmj.com/
Alternative URI http://dx.doi.org/10.1136/bjsm.2008.046532
Copyright Statement Copyright remains with the authors 2008. The attached file is posted here with permission of the copyright owners for your personal use only. No further distribution permitted. For information about this journal please refer to the publisher's website or contact the authors.
Volume 44
Page from 227
Page to 231
ISSN 1473-0480
Date Accessioned 2009-03-13
Date Available 2011-09-07T06:12:08Z
Language en_AU
Research Centre Griffith Health Institute; Heart Foundation Research Centre; Molecular Basis of Disease
Faculty Griffith Health Faculty
Subject Innate Immunity
URI http://hdl.handle.net/10072/22113
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1

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