Role of thioredoxin-1 in apoptosis induction by α-tocopheryl succinate and TNF-related apoptosis-inducing ligand in mesothelioma cells
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| Title | Role of thioredoxin-1 in apoptosis induction by α-tocopheryl succinate and TNF-related apoptosis-inducing ligand in mesothelioma cells |
|---|---|
| Author | Freeman, Ruth; Neuzil, Jiri |
| Journal Name | FEBS Letters |
| Year Published | 2006 |
| Place of publication | Netherlands |
| Publisher | Elsevier BV |
| Abstract | Malignant mesothelioma (MM) is a fatal type of cancer. We studied the role of the redox-active protein thioredoxin-1 (Trx-1) in apoptosis induced in MM cells and their non-malignant counterparts (Met-5A) by a-tocopheryl succinate (α-TOS) and TNF-related apoptosis-inducing ligand (TRAIL). MM cells were susceptible to a-TOS and less to TRAIL, while Met-5A cells were susceptible to TRAIL and resistant to α-TOS. MM cells expressed very low level of the Trx-1 protein, which was high in Met-5A cells, while the level of Trx-1 mRNA was similar in all cell lines. Downregulation of Trx-1 further sensitised Met-5A cells to TRAIL but not to α-TOS. Our data suggest that the role of Trx-1 in apoptosis modulation is unrelated to its anti-oxidant properties. |
| Peer Reviewed | Yes |
| Published | Yes |
| Publisher URI | http://www.sciencedirect.com/science/journal/00145793 |
| Alternative URI | http://dx.doi.org/10.1016/j.febslet.2006.04.019 |
| Copyright Statement | Copyright 2006 Elsevier. Please refer to the journal's website for access to the definitive, published version. |
| Volume | 580 |
| Issue Number | 11 |
| Page from | 2671 |
| Page to | 2676 |
| ISSN | 0014-5793 |
| Date Accessioned | 2009-04-08 |
| Date Available | 2009-09-09T07:18:08Z |
| Language | en_AU |
| Research Centre | Griffith Health Institute; Heart Foundation Research Centre; Molecular Basis of Disease |
| Faculty | Griffith Health Faculty |
| Subject | Cancer Cell Biology |
| URI | http://hdl.handle.net/10072/22118 |
| Publication Type | Journal Articles (Refereed Article) |
| Publication Type Code | c1a |
Please use this identifier to cite this record: http://hdl.handle.net/10072/22118
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