Role of thioredoxin-1 in apoptosis induction by α-tocopheryl succinate and TNF-related apoptosis-inducing ligand in mesothelioma cells

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Title Role of thioredoxin-1 in apoptosis induction by α-tocopheryl succinate and TNF-related apoptosis-inducing ligand in mesothelioma cells
Author Freeman, Ruth; Neuzil, Jiri
Journal Name FEBS Letters
Year Published 2006
Place of publication Netherlands
Publisher Elsevier BV
Abstract Malignant mesothelioma (MM) is a fatal type of cancer. We studied the role of the redox-active protein thioredoxin-1 (Trx-1) in apoptosis induced in MM cells and their non-malignant counterparts (Met-5A) by a-tocopheryl succinate (α-TOS) and TNF-related apoptosis-inducing ligand (TRAIL). MM cells were susceptible to a-TOS and less to TRAIL, while Met-5A cells were susceptible to TRAIL and resistant to α-TOS. MM cells expressed very low level of the Trx-1 protein, which was high in Met-5A cells, while the level of Trx-1 mRNA was similar in all cell lines. Downregulation of Trx-1 further sensitised Met-5A cells to TRAIL but not to α-TOS. Our data suggest that the role of Trx-1 in apoptosis modulation is unrelated to its anti-oxidant properties.
Peer Reviewed Yes
Published Yes
Publisher URI http://www.sciencedirect.com/science/journal/00145793
Alternative URI http://dx.doi.org/10.1016/j.febslet.2006.04.019
Copyright Statement Copyright 2006 Elsevier. Please refer to the journal's website for access to the definitive, published version.
Volume 580
Issue Number 11
Page from 2671
Page to 2676
ISSN 0014-5793
Date Accessioned 2009-04-08
Language en_AU
Research Centre Griffith Health Institute; Molecular Basis of Disease
Faculty Griffith Health Faculty
Subject Cancer Cell Biology
URI http://hdl.handle.net/10072/22118
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1a

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