Phase variable restriction-modification systems in Moraxella catarrhalis

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Title Phase variable restriction-modification systems in Moraxella catarrhalis
Author Seib, Kate L.; Peak, Ian; Jennings, Michael Paul
Journal Name FEMS Immunology and Medical Microbiology
Year Published 2002
Place of publication United Kingdom
Publisher Wiley-Blackwell Publishing Ltd.
Abstract A repetitive DNA motif was used as a marker to identify novel genes in the mucosal pathogen Moraxella catarrhalis. There is a high prevalence of such repetitive motifs in virulence genes that display phase variable expression. Two repeat containing loci were identified using a digoxigenin-labelled 5P-(CAAC)6-3'P oligonucleotide probe. The repeats are located in the methylase components of two distinct type III restriction-modification (R-M) systems. We suggest that the phase variable nature of these R-M systems indicates that they have an important role in the biology of M. catarrhalis.
Peer Reviewed Yes
Published Yes
Alternative URI http://dx.doi.org/10.1111/j.1574-695X.2002.tb00548.x
Volume 32
Issue Number 2
Page from 159
Page to 165
ISSN 0928-8244
Date Accessioned 2009-04-08
Language en_US
Research Centre Institute for Glycomics
Faculty Griffith Health Faculty
Subject PRE2009-Infectious Diseases
URI http://hdl.handle.net/10072/22119
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1x

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