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dc.contributor.authorSergeev, A.
dc.contributor.authorSergeev, A.
dc.contributor.authorPetrishchenko, V.
dc.contributor.authorShishkina, L.
dc.contributor.authorKochneva, G.
dc.contributor.authorZhukov, V.
dc.contributor.authorEvtin, N.
dc.contributor.authorPyankov, O.
dc.contributor.authorSandakhchiyev, L.
dc.contributor.authorAkinfeeva, L.
dc.contributor.authorUdut, V.
dc.contributor.authorSherstoboyev, E.
dc.contributor.authorGoldberg, E.
dc.contributor.authorMelnikov, S.
dc.contributor.authorPodkuiko, V.
dc.contributor.authorMaximov, V.
dc.contributor.editorDmitrii K Lvov
dc.date.accessioned2017-05-03T16:55:44Z
dc.date.available2017-05-03T16:55:44Z
dc.date.issued2004
dc.date.modified2009-04-16T06:53:13Z
dc.identifier.issn05074088
dc.identifier.urihttp://hdl.handle.net/10072/22169
dc.description.abstractThe reactogenicity of the embryonic live recombinant variola and hepatitis B bivaccine as tablets (Revax-BT) as well as its safety and immunogenicity were evaluated in clinical trials made in volunteers who had previously immunized or not with variola vaccine. A preliminary conclusion was made on a lack of side effects and drug safety in primary vaccination and been revaccination with low and high doses. Primary immunization of volunteers and as bivaccination with high doses stimulated the most pronounced immune response to the vaccine virus versus such effect observed in immunization of volunteers with low vaccine doses. Humoral immune response to HBs was observed in 75% of volunteers of both groups after as bivaccination. Such response was most pronounced in examinees immunized with low vaccine doses versus those who received high bivaccine doses. At the same time, no protective levels of humoral immunity response to HBs Ag were observed in volunteers first vaccinated.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageRussian
dc.language.isorus
dc.publisherIzdatel'stvo Meditsina
dc.publisher.placeRussian Federation
dc.publisher.urihttp://www.ncbi.nlm.nih.gov/pubmed/15529859
dc.relation.ispartofpagefrom22
dc.relation.ispartofpageto26
dc.relation.ispartofissue5
dc.relation.ispartofjournalVoprosy Virusologii
dc.relation.ispartofvolume49
dc.subject.fieldofresearchcode270304
dc.titleReactogenicity, safety and immunogenicity of a recombinant bivaccine against smallpox and hepatitis B in limited clinical trials
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2004
gro.hasfulltextNo Full Text
gro.griffith.authorPyankov, Oleg


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