Reactogenicity, safety and immunogenicity of a recombinant bivaccine against smallpox and hepatitis B in limited clinical trials

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Title Reactogenicity, safety and immunogenicity of a recombinant bivaccine against smallpox and hepatitis B in limited clinical trials
Author Sergeev, A. A.; Sergeev, A. N.; Petrishchenko, V. A.; Shishkina, L. N.; Kochneva, G. V.; Zhukov, V. A.; Evtin, N. K.; Pyankov, Oleg; Sandakhchiyev, L. S.; Akinfeeva, L. A.; Udut, V. V.; Sherstoboyev, E. Yu.; Goldberg, E. D.; Melnikov, S. A.; Podkuiko, V. N.; Maximov, V. A.
Journal Name Voprosy virusologii
Editor Dmitrii K Lvov
Year Published 2004
Place of publication Russian Federation
Publisher Izdatel'stvo Meditsina
Abstract The reactogenicity of the embryonic live recombinant variola and hepatitis B bivaccine as tablets (Revax-BT) as well as its safety and immunogenicity were evaluated in clinical trials made in volunteers who had previously immunized or not with variola vaccine. A preliminary conclusion was made on a lack of side effects and drug safety in primary vaccination and been revaccination with low and high doses. Primary immunization of volunteers and as bivaccination with high doses stimulated the most pronounced immune response to the vaccine virus versus such effect observed in immunization of volunteers with low vaccine doses. Humoral immune response to HBs was observed in 75% of volunteers of both groups after as bivaccination. Such response was most pronounced in examinees immunized with low vaccine doses versus those who received high bivaccine doses. At the same time, no protective levels of humoral immunity response to HBs Ag were observed in volunteers first vaccinated.
Peer Reviewed Yes
Published Yes
Publisher URI http://www.ncbi.nlm.nih.gov/pubmed/15529859
Volume 49
Issue Number 5
Page from 22
Page to 26
ISSN 0507-4088
Date Accessioned 2009-04-07
Language en_AU
Faculty Faculty of Science, Environment, Engineering and Technology
Subject PRE2009-Infectious Agents
URI http://hdl.handle.net/10072/22169
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1x

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