Antiviral activity of oral ultra low doses of antibodies to gamma-interferon: experimental study of influenza infection in mice

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Title Antiviral activity of oral ultra low doses of antibodies to gamma-interferon: experimental study of influenza infection in mice
Author Sergeyev, A. N.; Pyankov, Oleg; Shishkina, L. N.; Duben, L. G.; Petrishchenko, V. A.; Zhukov, V. A.; Pyankova, O. G.; Svyatchenko, L. I.; Sherstoboyev, E. Yu.; Karimova, T. V.; Martyushev-Poklad, A. V.; Sergeeva, S. A.; Epstein, O. I.; Glotov, A. G.; Glotova, T. G.
Journal Name Voprosy virusologii
Editor Dmitrii K Lvov
Year Published 2004
Place of publication Russian Federation
Publisher Izdatel'stvo Meditsina
Abstract Course intragastric administration of ultralow doses of human gamma-interferon antibodies (ULD anti-IFN-gamma) to intact mice resulted in an increase of endogenous IFN-gamma production by the animal lymphocytes. Oral prophylactic administration of ULD anti-IFN-gamma significantly lowered the influenza virus concentration in the animal lungs at the initial stage of the aerogenous infection: in 2 (p = 0.05) and 3 (p = 0.07) days after the contamination. The therapeutic antiviral effect of ULD anti-IFN-gamma in mice with influenza was evident from a significant decrease of the influenza virus concentration in the lungs of the animals on the 4th (p = 0.05) and 5th (p = 0.07) days after the contamination. The antiviral effect of ULD anti-IFN-gamma after the prophylactic and therapeutic use is likely provided by induction of endogenous IFN-gamma
Peer Reviewed Yes
Published Yes
Publisher URI http://www.ncbi.nlm.nih.gov/pubmed/15945542
Volume 49
Issue Number 11
Page from 7
Page to 11
ISSN 0507-4088
Date Accessioned 2009-04-07
Date Available 2009-04-16T06:53:19Z
Language en_AU
Faculty Faculty of Science, Environment, Engineering and Technology
Subject PRE2009-Infectious Agents
URI http://hdl.handle.net/10072/22171
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1x

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