Antiviral activity of oral ultra low doses of antibodies to gamma-interferon: experimental study of influenza infection in mice
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| Title | Antiviral activity of oral ultra low doses of antibodies to gamma-interferon: experimental study of influenza infection in mice |
|---|---|
| Author | Sergeyev, A. N.; Pyankov, Oleg; Shishkina, L. N.; Duben, L. G.; Petrishchenko, V. A.; Zhukov, V. A.; Pyankova, O. G.; Svyatchenko, L. I.; Sherstoboyev, E. Yu.; Karimova, T. V.; Martyushev-Poklad, A. V.; Sergeeva, S. A.; Epstein, O. I.; Glotov, A. G.; Glotova, T. G. |
| Journal Name | Voprosy virusologii |
| Editor | Dmitrii K Lvov |
| Year Published | 2004 |
| Place of publication | Russian Federation |
| Publisher | Izdatel'stvo Meditsina |
| Abstract | Course intragastric administration of ultralow doses of human gamma-interferon antibodies (ULD anti-IFN-gamma) to intact mice resulted in an increase of endogenous IFN-gamma production by the animal lymphocytes. Oral prophylactic administration of ULD anti-IFN-gamma significantly lowered the influenza virus concentration in the animal lungs at the initial stage of the aerogenous infection: in 2 (p = 0.05) and 3 (p = 0.07) days after the contamination. The therapeutic antiviral effect of ULD anti-IFN-gamma in mice with influenza was evident from a significant decrease of the influenza virus concentration in the lungs of the animals on the 4th (p = 0.05) and 5th (p = 0.07) days after the contamination. The antiviral effect of ULD anti-IFN-gamma after the prophylactic and therapeutic use is likely provided by induction of endogenous IFN-gamma |
| Peer Reviewed | Yes |
| Published | Yes |
| Publisher URI | http://www.ncbi.nlm.nih.gov/pubmed/15945542 |
| Volume | 49 |
| Issue Number | 11 |
| Page from | 7 |
| Page to | 11 |
| ISSN | 0507-4088 |
| Date Accessioned | 2009-04-07 |
| Date Available | 2009-04-16T06:53:19Z |
| Language | en_AU |
| Faculty | Faculty of Science, Environment, Engineering and Technology |
| Subject | PRE2009-Infectious Agents |
| URI | http://hdl.handle.net/10072/22171 |
| Publication Type | Journal Articles (Refereed Article) |
| Publication Type Code | c1x |
Please use this identifier to cite this record: http://hdl.handle.net/10072/22171
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