Pulmonary cell susceptibility in mice and rats to influenza virus when infected in vivo and in vitro

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Title Pulmonary cell susceptibility in mice and rats to influenza virus when infected in vivo and in vitro
Author Sergeev, A. A.; Shishkina, L. N.; Zhukov, V. A.; Sergeev, A. N.; Petrishchenko, V. A.; Fankin, I. V.; Pyankov, Oleg; Ryabchikova, E. I.; Malkova, E. M.; Vorobyov, A. A.
Journal Name Rossiiskaya Akademiya Meditsinskikh Nauk. Vestnik
Editor Nikolai P Bochkov
Year Published 2004
Place of publication Russian Federation
Publisher Izdatel'stvo Meditsina
Abstract The purpose of the case study was to evaluate comparatively the relative contribution of cell susceptibility and the inhibiting effect of factors of pulmonary epithelial lining in mice and rats to influenza virus A/Aichi/2/68 (H3N2) adapted to mice as related with the development of infection process in the lungs of experimental animals when infected in vivo and in vitro. Mice and rats were infected aerogenically with different doses of influenza virus. The primary cell-culture suspensions sampled from the lungs of mice and rats were used to study the adsorption and dynamics of influenza virus production in infection by different dose of influenza virus in vitro. The cell suspensions were shown to be able to produce the influenza virus for as long as 48 hours after infection. It was for the first time that the results denoted the identical susceptibility of primary pulmonary cells in mice and rats to influenza virus. A lower pulmonary susceptibility to influenza virus in rats versus mice could be indicative of that the surface factors of epithelial lining contribute essentially to shaping the pulmonary susceptibility to influenza virus since there is no difference of the susceptibility of pulmonary cells to influenza virus between the two above animals' species.
Peer Reviewed Yes
Published Yes
Publisher URI http://www.ncbi.nlm.nih.gov/pubmed/15455685
Volume 2004
Issue Number 8
Page from 15
Page to 18
ISSN 0869-6047
Date Accessioned 2009-04-06
Date Available 2009-04-16T06:53:53Z
Language en_AU
Faculty Faculty of Science, Environment, Engineering and Technology
Subject PRE2009-Infectious Agents
URI http://hdl.handle.net/10072/22182
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1x

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