Rational design of potent sialidase-based inhibitors of influenza virus replication

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Title Rational design of potent sialidase-based inhibitors of influenza virus replication
Author Itzstein, Mark von; Wu, Wen-Yang; Kok, Gaik B.; Pegg, Michael S.; Dyason, Jeffrey Clifford; Jin, Betty; Phan, Tho Van; Smythe, Mark L.; White, Hume F.; Oliver, Stuart W.; Colman, Peter M.; Varghese, Joseph N.; Ryan, D. Michael; Woods, Jacqueline M.; Bethell, Richard C.; Hotham, Vanessa J.; Cameron, Janet M.; Penn, Charles R.
Journal Name Nature: International weekly journal of science
Year Published 1993
Place of publication United Kingdom
Publisher Nature Publishing Group
Abstract Two potent inhibitors based on the crystal structure of influenza virus sialidase have been designed. These compounds are effective inhibitors not only of the enzyme, but also of the virus in cell culture and in animal models. The results provide an example of the power of rational, computer-assisted drug design, as well as indicating significant progress in the development of a new therapeutic or prophylactic treatment for influenza infection.
Peer Reviewed Yes
Published Yes
Alternative URI http://dx.doi.org/10.1038/363418a0
Volume 363
Issue Number 6428
Page from 418
Page to 423
ISSN 0028-0836
Date Accessioned 2009-04-03
Date Available 2009-04-17T05:30:47Z
Language en_AU
Faculty Faculty of Science, Environment, Engineering and Technology
Subject Biochemistry and Cell Biology
URI http://hdl.handle.net/10072/22238
Publication Type Article in Scholarly refereed Journal
Publication Type Code c1x

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