Rational design of potent sialidase-based inhibitors of influenza virus replication
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| Title | Rational design of potent sialidase-based inhibitors of influenza virus replication |
|---|---|
| Author | Itzstein, Mark von; Wu, Wen-Yang; Kok, Gaik B.; Pegg, Michael S.; Dyason, Jeffrey Clifford; Jin, Betty; Phan, Tho Van; Smythe, Mark L.; White, Hume F.; Oliver, Stuart W.; Colman, Peter M.; Varghese, Joseph N.; Ryan, D. Michael; Woods, Jacqueline M.; Bethell, Richard C.; Hotham, Vanessa J.; Cameron, Janet M.; Penn, Charles R. |
| Journal Name | Nature: International weekly journal of science |
| Year Published | 1993 |
| Place of publication | United Kingdom |
| Publisher | Nature Publishing Group |
| Abstract | Two potent inhibitors based on the crystal structure of influenza virus sialidase have been designed. These compounds are effective inhibitors not only of the enzyme, but also of the virus in cell culture and in animal models. The results provide an example of the power of rational, computer-assisted drug design, as well as indicating significant progress in the development of a new therapeutic or prophylactic treatment for influenza infection. |
| Peer Reviewed | Yes |
| Published | Yes |
| Alternative URI | http://dx.doi.org/10.1038/363418a0 |
| Volume | 363 |
| Issue Number | 6428 |
| Page from | 418 |
| Page to | 423 |
| ISSN | 0028-0836 |
| Date Accessioned | 2009-04-03 |
| Date Available | 2009-04-17T05:30:47Z |
| Language | en_AU |
| Faculty | Faculty of Science, Environment, Engineering and Technology |
| Subject | Biochemistry and Cell Biology |
| URI | http://hdl.handle.net/10072/22238 |
| Publication Type | Article in Scholarly refereed Journal |
| Publication Type Code | c1x |
Please use this identifier to cite this record: http://hdl.handle.net/10072/22238
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