A study of possibility to predict the sensitivity of different respiratory tract divisions to influenza

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Title A study of possibility to predict the sensitivity of different respiratory tract divisions to influenza
Author Zhukov, V. A.; Shishkina, L. N.; Sergeyev, A. A.; Fankin, I. V.; Smetannikova, M. A.; Pyankov, Oleg; Petrischenko, V. A.; Sergeyev, A. N.; Vorobyov, A. A.
Journal Name Rossiiskaya Akademiya Meditsinskikh Nauk. Vestnik
Editor Nikolai P Bochkov
Year Published 2007
Place of publication Russian Federation
Publisher Izdatel'stvo Meditsina
Abstract To predict a potential value of a viral ID50 for a macro-organism of interest (e.g. humans), it is necessary to determine in vitro two parameters of the interaction of the virus with susceptible cells of the host, i.e. the probability of the virus' productive absorption on a susceptible cell and the average virus yield per cell. A different macroorganism (a model animal) and primary cells obtained from it can be used to determine the value of a scale factor, which accounts for the difference between the values of the probability of the virus' absorption measured in vivo and in vitro. An original mathematical model is used to convert the above-mentioned data to ID50 for the macroorganism of interest. It was shown that the method of cultivating influenza virus (A/ Aichi/2/68) in primary suspension culture of respiratory tract cells of rats and two breeds of mice may be used to estimate potential human susceptibility to novel influenza viruses. This work was sponsored by DAPRA, USA, and performed under the contract 450p to the International Science and Technology Center, Moscow.
Peer Reviewed Yes
Published Yes
Publisher URI http://www.ncbi.nlm.nih.gov/pubmed/17601039
Volume 2007
Issue Number 5
Page from 32
Page to 37
ISSN 0869-6047
Date Accessioned 2009-04-14
Language en_AU
Faculty Faculty of Science, Environment, Engineering and Technology
Subject PRE2009-Infectious Agents
URI http://hdl.handle.net/10072/22243
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1x

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